Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review
In recent years, the incidence of cancers, inflammatory diseases, Alzheimer’s disease, glucose metabolism disorder and diabetes has increased alarmingly which demands more research into the discovery of new drug candidates to treat these human diseases. Main phytochemicals from Humulus lupulus L. (h...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2024-01-01
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| Series: | Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ps.tbzmed.ac.ir/PDF/ps-30-1.pdf |
| _version_ | 1797322269166403584 |
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| author | Ferah Comert Onder Sevil Kalin Nebahat Sahin Gulce Davutlar Khaled A.N. Abusharkh Ozlem Maraba Rabia Selina Hal Mehmet Ay Lutfun Nahar Satyajit D. Sarker |
| author_facet | Ferah Comert Onder Sevil Kalin Nebahat Sahin Gulce Davutlar Khaled A.N. Abusharkh Ozlem Maraba Rabia Selina Hal Mehmet Ay Lutfun Nahar Satyajit D. Sarker |
| author_sort | Ferah Comert Onder |
| collection | DOAJ |
| description | In recent years, the incidence of cancers, inflammatory diseases, Alzheimer’s disease, glucose metabolism disorder and diabetes has increased alarmingly which demands more research into the discovery of new drug candidates to treat these human diseases. Main phytochemicals from Humulus lupulus L. (hops) have been demonstrated to have positive impacts on human health, and prenylated flavonoids are one of the major groups of bioactive phytochemicals found in this plant. Thus, this review summarizes the role of major prenylated components in hops in human diseases including cancer, inflammation and viral infections. In silico studies of prenylated bioactive compounds against various drug targets such as histone deactylases (HDACs), sirtuins (SIRTs), and acetylcholinesterase (AChE), and the molecular molecular interactions between protein and ligand have also been included. Furthermore, the structure-activity relationships (SAR) studies on these compounds are highlighted. This review concludes that the prenylated phytochemicals from H. lupulus L., including xanthohumol (XN), isoxanthohumol (IXN), 8-prenylnaringenin (8-PN) and 6-prenylnaringenin (6-PN), have promising roles in human health and may contribute to new drug discovery and development. |
| first_indexed | 2024-03-08T05:11:46Z |
| format | Article |
| id | doaj.art-0f256e5e65f14878a966a23f31e03ba8 |
| institution | Directory Open Access Journal |
| issn | 2383-2886 |
| language | English |
| last_indexed | 2024-03-08T05:11:46Z |
| publishDate | 2024-01-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical Sciences |
| spelling | doaj.art-0f256e5e65f14878a966a23f31e03ba82024-02-07T06:27:26ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862024-01-0130112010.34172/PS.2023.18ps-39772Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A ReviewFerah Comert Onder0Sevil Kalin1Nebahat Sahin2Gulce Davutlar3Khaled A.N. Abusharkh4Ozlem Maraba5Rabia Selina Hal6Mehmet Ay7Lutfun Nahar8Satyajit D. Sarker9Department of Medical Biology, Çanakkale Onsekiz Mart University, Faculty of Medicine, 17020, Çanakkale, Türkiye.Department of Medical System Biology, Çanakkale Onsekiz Mart University, School of Graduate Students, 17020, Çanakkale, Türkiye.Department of Medical System Biology, Çanakkale Onsekiz Mart University, School of Graduate Students, 17020, Çanakkale, Türkiye.Department of Medical System Biology, Çanakkale Onsekiz Mart University, School of Graduate Students, 17020, Çanakkale, Türkiye.Department of Chemistry, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Faculty of Science, 17020, Çanakkale, Türkiye.Department of Medical System Biology, Çanakkale Onsekiz Mart University, School of Graduate Students, 17020, Çanakkale, Türkiye.Çanakkale Onsekiz Mart University, Faculty of Medicine, 17020, Çanakkale, Türkiye.Department of Chemistry, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Faculty of Science, 17020, Çanakkale, Türkiye.Laboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Šlechtitelů 27, 78371 Olomouc, Czech Republic.Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom.In recent years, the incidence of cancers, inflammatory diseases, Alzheimer’s disease, glucose metabolism disorder and diabetes has increased alarmingly which demands more research into the discovery of new drug candidates to treat these human diseases. Main phytochemicals from Humulus lupulus L. (hops) have been demonstrated to have positive impacts on human health, and prenylated flavonoids are one of the major groups of bioactive phytochemicals found in this plant. Thus, this review summarizes the role of major prenylated components in hops in human diseases including cancer, inflammation and viral infections. In silico studies of prenylated bioactive compounds against various drug targets such as histone deactylases (HDACs), sirtuins (SIRTs), and acetylcholinesterase (AChE), and the molecular molecular interactions between protein and ligand have also been included. Furthermore, the structure-activity relationships (SAR) studies on these compounds are highlighted. This review concludes that the prenylated phytochemicals from H. lupulus L., including xanthohumol (XN), isoxanthohumol (IXN), 8-prenylnaringenin (8-PN) and 6-prenylnaringenin (6-PN), have promising roles in human health and may contribute to new drug discovery and development.https://ps.tbzmed.ac.ir/PDF/ps-30-1.pdfcancerhumulus lupulus l.in silicophytotherapeuticspreclinical trialxanthohumol |
| spellingShingle | Ferah Comert Onder Sevil Kalin Nebahat Sahin Gulce Davutlar Khaled A.N. Abusharkh Ozlem Maraba Rabia Selina Hal Mehmet Ay Lutfun Nahar Satyajit D. Sarker Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review Pharmaceutical Sciences cancer humulus lupulus l. in silico phytotherapeutics preclinical trial xanthohumol |
| title | Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review |
| title_full | Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review |
| title_fullStr | Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review |
| title_full_unstemmed | Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review |
| title_short | Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review |
| title_sort | major bioactive prenylated flavonoids from humulus lupulus l their applications in human diseases and structure activity relationships sar a review |
| topic | cancer humulus lupulus l. in silico phytotherapeutics preclinical trial xanthohumol |
| url | https://ps.tbzmed.ac.ir/PDF/ps-30-1.pdf |
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