Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model

Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model

Neurofibromatosis Type 1 (NF1) is one of the most common genetically inherited disorders that affects 1 in 3000 children annually. Clinical manifestations vary widely but nearly always include the development of cutaneous, plexiform and diffuse neurofibromas that are managed over many years. Recent...

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Bibliographic Details
Main Authors: Dalton T. McLean, Jennifer J. Meudt, Loren D. Lopez Rivera, Dominic T. Schomberg, Derek M. Pavelec, Tyler T. Duellman, Darya G. Buehler, Patrick B. Schwartz, Melissa Graham, Laura M. Lee, Keri D. Graff, Jamie L. Reichert, Sandra S. Bon-Durant, Charles M. Konsitzke, Sean M. Ronnekleiv-Kelly, Dhanansayan Shanmuganayagam, C. Dustin Rubinstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
neurofibromatosis type 1 (NF1)
single cell RNA seq
swine
tumor microenvironment (TME)
neurofibroma
cancer-associated fibroblasts (CAF)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1253659/full

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