Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04116-9 |
| _version_ | 1818341919569215488 |
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| author | Carolin Seuring Kartik Ayyer Eleftheria Filippaki Miriam Barthelmess Jean-Nicolas Longchamp Philippe Ringler Tommaso Pardini David H. Wojtas Matthew A. Coleman Katerina Dörner Silje Fuglerud Greger Hammarin Birgit Habenstein Annette E. Langkilde Antoine Loquet Alke Meents Roland Riek Henning Stahlberg Sébastien Boutet Mark S. Hunter Jason Koglin Mengning Liang Helen M. Ginn Rick P. Millane Matthias Frank Anton Barty Henry N. Chapman |
| author_facet | Carolin Seuring Kartik Ayyer Eleftheria Filippaki Miriam Barthelmess Jean-Nicolas Longchamp Philippe Ringler Tommaso Pardini David H. Wojtas Matthew A. Coleman Katerina Dörner Silje Fuglerud Greger Hammarin Birgit Habenstein Annette E. Langkilde Antoine Loquet Alke Meents Roland Riek Henning Stahlberg Sébastien Boutet Mark S. Hunter Jason Koglin Mengning Liang Helen M. Ginn Rick P. Millane Matthias Frank Anton Barty Henry N. Chapman |
| author_sort | Carolin Seuring |
| collection | DOAJ |
| description | The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser. |
| first_indexed | 2024-12-13T16:06:27Z |
| format | Article |
| id | doaj.art-0f29de3d658a4701815f6d96e5366ab4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:06:27Z |
| publishDate | 2018-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0f29de3d658a4701815f6d96e5366ab42022-12-21T23:39:02ZengNature PortfolioNature Communications2041-17232018-05-019111010.1038/s41467-018-04116-9Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background grapheneCarolin Seuring0Kartik Ayyer1Eleftheria Filippaki2Miriam Barthelmess3Jean-Nicolas Longchamp4Philippe Ringler5Tommaso Pardini6David H. Wojtas7Matthew A. Coleman8Katerina Dörner9Silje Fuglerud10Greger Hammarin11Birgit Habenstein12Annette E. Langkilde13Antoine Loquet14Alke Meents15Roland Riek16Henning Stahlberg17Sébastien Boutet18Mark S. Hunter19Jason Koglin20Mengning Liang21Helen M. Ginn22Rick P. Millane23Matthias Frank24Anton Barty25Henry N. Chapman26Center for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronPhysics Department of the University of ZurichCenter for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of BaselLawrence Livermore National LaboratoryDepartment of Electrical and Computer Engineering, University of CanterburyLawrence Livermore National LaboratoryCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronDepartment of Chemistry and Molecular BiologyCNRS, CBMN UMR5248, IECB, Université de BordeauxDepartment of Drug Design and Pharmacology, University of CopenhagenCNRS, CBMN UMR5248, IECB, Université de BordeauxCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronLaboratory of Physical Chemistry, ETH ZürichCenter for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of BaselLinac Coherent Light Source, SLAC National Accelerator LaboratoryLinac Coherent Light Source, SLAC National Accelerator LaboratoryLinac Coherent Light Source, SLAC National Accelerator LaboratoryLinac Coherent Light Source, SLAC National Accelerator LaboratoryDivision of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of OxfordDepartment of Electrical and Computer Engineering, University of CanterburyLawrence Livermore National LaboratoryCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronThe structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.https://doi.org/10.1038/s41467-018-04116-9 |
| spellingShingle | Carolin Seuring Kartik Ayyer Eleftheria Filippaki Miriam Barthelmess Jean-Nicolas Longchamp Philippe Ringler Tommaso Pardini David H. Wojtas Matthew A. Coleman Katerina Dörner Silje Fuglerud Greger Hammarin Birgit Habenstein Annette E. Langkilde Antoine Loquet Alke Meents Roland Riek Henning Stahlberg Sébastien Boutet Mark S. Hunter Jason Koglin Mengning Liang Helen M. Ginn Rick P. Millane Matthias Frank Anton Barty Henry N. Chapman Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene Nature Communications |
| title | Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene |
| title_full | Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene |
| title_fullStr | Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene |
| title_full_unstemmed | Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene |
| title_short | Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene |
| title_sort | femtosecond x ray coherent diffraction of aligned amyloid fibrils on low background graphene |
| url | https://doi.org/10.1038/s41467-018-04116-9 |
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