A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds
Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limi...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/13/3050 |
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| author | Yujie Chen Runjing Zhang Baiqin Zheng Chao Cai Zhen Chen Hua Li Hezhou Liu |
| author_facet | Yujie Chen Runjing Zhang Baiqin Zheng Chao Cai Zhen Chen Hua Li Hezhou Liu |
| author_sort | Yujie Chen |
| collection | DOAJ |
| description | Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3′-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications. |
| first_indexed | 2024-03-10T18:41:13Z |
| format | Article |
| id | doaj.art-0f2a1c5d30f04e408c9452f376ea4601 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:41:13Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0f2a1c5d30f04e408c9452f376ea46012023-11-20T05:47:18ZengMDPI AGMolecules1420-30492020-07-012513305010.3390/molecules25133050A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic BondsYujie Chen0Runjing Zhang1Baiqin Zheng2Chao Cai3Zhen Chen4Hua Li5Hezhou Liu6State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Pharmaceutical and Material Engineering, Jinhua Polytechnic, Jinhua 321017, Zhejiang Province, ChinaState Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, ChinaInjectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3′-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.https://www.mdpi.com/1420-3049/25/13/3050injectable hydrogeltriple dynamic bondsnatural polysaccharide derivativesbiocompatiblestimuli-responsive |
| spellingShingle | Yujie Chen Runjing Zhang Baiqin Zheng Chao Cai Zhen Chen Hua Li Hezhou Liu A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds Molecules injectable hydrogel triple dynamic bonds natural polysaccharide derivatives biocompatible stimuli-responsive |
| title | A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds |
| title_full | A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds |
| title_fullStr | A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds |
| title_full_unstemmed | A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds |
| title_short | A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds |
| title_sort | biocompatible stimuli responsive and injectable hydrogel with triple dynamic bonds |
| topic | injectable hydrogel triple dynamic bonds natural polysaccharide derivatives biocompatible stimuli-responsive |
| url | https://www.mdpi.com/1420-3049/25/13/3050 |
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