A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients
Coronavirus disease 2019 (COVID-19) is a global public health emergency with many clinical facets, and new knowledge about its pathogenetic mechanisms is deemed necessary; among these, there are certainly coagulation disorders. In the history of medicine, autopsies and tissue sampling have played a...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-11-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1810224 |
| _version_ | 1797684180615692288 |
|---|---|
| author | Luca Roncati Giulia Ligabue Vincenzo Nasillo Beatrice Lusenti William Gennari Luca Fabbiani Claudia Malagoli Graziana Gallo Silvia Giovanella Massimo Lupi Tiziana Salviato Ambra Paolini Matteo Costantini Tommaso Trenti Antonio Maiorana |
| author_facet | Luca Roncati Giulia Ligabue Vincenzo Nasillo Beatrice Lusenti William Gennari Luca Fabbiani Claudia Malagoli Graziana Gallo Silvia Giovanella Massimo Lupi Tiziana Salviato Ambra Paolini Matteo Costantini Tommaso Trenti Antonio Maiorana |
| author_sort | Luca Roncati |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is a global public health emergency with many clinical facets, and new knowledge about its pathogenetic mechanisms is deemed necessary; among these, there are certainly coagulation disorders. In the history of medicine, autopsies and tissue sampling have played a fundamental role in order to understand the pathogenesis of emerging diseases, including infectious ones; compared to the past, histopathology can be now expanded by innovative techniques and modern technologies. For the first time in worldwide literature, we provide a detailed postmortem and biopsy report on the marked increase, up to 1 order of magnitude, of naked megakaryocyte nuclei in the bone marrow and lungs from serious COVID-19 patients. Most likely related to high interleukin-6 serum levels stimulating megakaryocytopoiesis, this phenomenon concurs to explain well the pulmonary abnormal immunothrombosis in these critically ill patients, all without molecular or electron microscopy signs of megakaryocyte infection. |
| first_indexed | 2024-03-12T00:25:50Z |
| format | Article |
| id | doaj.art-0f2a358b4d5f43b698f926d5d5ac36c9 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:50Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-0f2a358b4d5f43b698f926d5d5ac36c92023-09-15T10:38:08ZengTaylor & Francis GroupPlatelets0953-71041369-16352020-11-013181085108910.1080/09537104.2020.18102241810224A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patientsLuca Roncati0Giulia Ligabue1Vincenzo Nasillo2Beatrice Lusenti3William Gennari4Luca Fabbiani5Claudia Malagoli6Graziana Gallo7Silvia Giovanella8Massimo Lupi9Tiziana Salviato10Ambra Paolini11Matteo Costantini12Tommaso Trenti13Antonio Maiorana14University of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity Hospital of ModenaUniversity Hospital of ModenaUniversity Hospital of ModenaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity of Modena and Reggio EmiliaUniversity Hospital of ModenaUniversity of Modena and Reggio EmiliaUniversity Hospital of ModenaUniversity of Modena and Reggio EmiliaCoronavirus disease 2019 (COVID-19) is a global public health emergency with many clinical facets, and new knowledge about its pathogenetic mechanisms is deemed necessary; among these, there are certainly coagulation disorders. In the history of medicine, autopsies and tissue sampling have played a fundamental role in order to understand the pathogenesis of emerging diseases, including infectious ones; compared to the past, histopathology can be now expanded by innovative techniques and modern technologies. For the first time in worldwide literature, we provide a detailed postmortem and biopsy report on the marked increase, up to 1 order of magnitude, of naked megakaryocyte nuclei in the bone marrow and lungs from serious COVID-19 patients. Most likely related to high interleukin-6 serum levels stimulating megakaryocytopoiesis, this phenomenon concurs to explain well the pulmonary abnormal immunothrombosis in these critically ill patients, all without molecular or electron microscopy signs of megakaryocyte infection.http://dx.doi.org/10.1080/09537104.2020.1810224coronavirus disease 2019 (covid-19)immunothrombosisinterleukin-6 (il-6)megakaryocytesnaked megakaryocyte nucleisevere acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| spellingShingle | Luca Roncati Giulia Ligabue Vincenzo Nasillo Beatrice Lusenti William Gennari Luca Fabbiani Claudia Malagoli Graziana Gallo Silvia Giovanella Massimo Lupi Tiziana Salviato Ambra Paolini Matteo Costantini Tommaso Trenti Antonio Maiorana A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients Platelets coronavirus disease 2019 (covid-19) immunothrombosis interleukin-6 (il-6) megakaryocytes naked megakaryocyte nuclei severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| title | A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients |
| title_full | A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients |
| title_fullStr | A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients |
| title_full_unstemmed | A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients |
| title_short | A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients |
| title_sort | proof of evidence supporting abnormal immunothrombosis in severe covid 19 naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients |
| topic | coronavirus disease 2019 (covid-19) immunothrombosis interleukin-6 (il-6) megakaryocytes naked megakaryocyte nuclei severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| url | http://dx.doi.org/10.1080/09537104.2020.1810224 |
| work_keys_str_mv | AT lucaroncati aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT giulialigabue aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT vincenzonasillo aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT beatricelusenti aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT williamgennari aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT lucafabbiani aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT claudiamalagoli aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT grazianagallo aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT silviagiovanella aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT massimolupi aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT tizianasalviato aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT ambrapaolini aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT matteocostantini aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT tommasotrenti aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT antoniomaiorana aproofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT lucaroncati proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT giulialigabue proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT vincenzonasillo proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT beatricelusenti proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT williamgennari proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT lucafabbiani proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT claudiamalagoli proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT grazianagallo proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT silviagiovanella proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT massimolupi proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT tizianasalviato proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT ambrapaolini proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT matteocostantini proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT tommasotrenti proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients AT antoniomaiorana proofofevidencesupportingabnormalimmunothrombosisinseverecovid19nakedmegakaryocytenucleiincreaseinthebonemarrowandlungsofcriticallyillpatients |