The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
Abstract There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-07532-x |
| _version_ | 1818840667177091072 |
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| author | Felice Contaldi Federico Capuano Andrea Fulgione Riccardo Aiese Cigliano Walter Sanseverino Domenico Iannelli Chiara Medaglia Rosanna Capparelli |
| author_facet | Felice Contaldi Federico Capuano Andrea Fulgione Riccardo Aiese Cigliano Walter Sanseverino Domenico Iannelli Chiara Medaglia Rosanna Capparelli |
| author_sort | Felice Contaldi |
| collection | DOAJ |
| description | Abstract There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the hallmarks of Alzheimer’s disease: APP, APOE, PSEN1, and PSEN2. A large fraction of modulated genes (30 out of 77) belong to the inflammation pathway. Remarkably, the pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis-regulated also in this study. The unsuspected links between such different diseases – though still awaiting formal validation – suggest new directions for the study of neurological diseases. |
| first_indexed | 2024-12-19T04:13:49Z |
| format | Article |
| id | doaj.art-0f2bfa7c363f4194810ee07e1fe11164 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:13:49Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0f2bfa7c363f4194810ee07e1fe111642022-12-21T20:36:20ZengNature PortfolioScientific Reports2045-23222017-08-017111410.1038/s41598-017-07532-xThe hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausibleFelice Contaldi0Federico Capuano1Andrea Fulgione2Riccardo Aiese Cigliano3Walter Sanseverino4Domenico Iannelli5Chiara Medaglia6Rosanna Capparelli7Department of Agriculture, University of Naples “Federico II”Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del MezzogiornoDepartment of Agriculture, University of Naples “Federico II”Sequentia Biotech, Edifici CRAG, Campus UAB, Bellaterra (Cerdanyola del Vallès)Sequentia Biotech, Edifici CRAG, Campus UAB, Bellaterra (Cerdanyola del Vallès)Department of Agriculture, University of Naples “Federico II”Department of Immunology, Weizmann Institute of ScienceDepartment of Agriculture, University of Naples “Federico II”Abstract There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the hallmarks of Alzheimer’s disease: APP, APOE, PSEN1, and PSEN2. A large fraction of modulated genes (30 out of 77) belong to the inflammation pathway. Remarkably, the pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis-regulated also in this study. The unsuspected links between such different diseases – though still awaiting formal validation – suggest new directions for the study of neurological diseases.https://doi.org/10.1038/s41598-017-07532-x |
| spellingShingle | Felice Contaldi Federico Capuano Andrea Fulgione Riccardo Aiese Cigliano Walter Sanseverino Domenico Iannelli Chiara Medaglia Rosanna Capparelli The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible Scientific Reports |
| title | The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible |
| title_full | The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible |
| title_fullStr | The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible |
| title_full_unstemmed | The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible |
| title_short | The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible |
| title_sort | hypothesis that helicobacter pylori predisposes to alzheimer s disease is biologically plausible |
| url | https://doi.org/10.1038/s41598-017-07532-x |
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