Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults
Background/Aims: Awareness of chronic kidney disease (CKD) has been low among affected patients, particularly the older ones. However, whether such awareness is synonymous with the presence of laboratory-diagnosed CKD among older adults is currently unclear. Methods: We enrolled community-dwelling o...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-12-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/496002 |
| _version_ | 1811206628971642880 |
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| author | Chia-Ter Chao Yi-Hsuan Lee Kuen-Cheh Yang Jen-Kuei Peng Chia-Ming Li Shih-I Chen Der-Sheng Han Jenq-Wen Huang COGENT study group |
| author_facet | Chia-Ter Chao Yi-Hsuan Lee Kuen-Cheh Yang Jen-Kuei Peng Chia-Ming Li Shih-I Chen Der-Sheng Han Jenq-Wen Huang COGENT study group |
| author_sort | Chia-Ter Chao |
| collection | DOAJ |
| description | Background/Aims: Awareness of chronic kidney disease (CKD) has been low among affected patients, particularly the older ones. However, whether such awareness is synonymous with the presence of laboratory-diagnosed CKD among older adults is currently unclear. Methods: We enrolled community-dwelling old adults (≥ 65 years) who received health examinations between 2013 and 2016 from a regional metropolitan hospital. Clinical information and geriatric syndromes including depression, cognitive impairment, fall, quality of life, and visual disturbance were evaluated during the medical interview. We compared the differences in clinical features between those with and without self-reported or estimated glomerular filtration rate (eGFR)-based CKD and investigated their influences and interactions on the risk of CKD complications and geriatric syndromes. Results: Among the 2932 enrolled older adults (mean 73.4 ± 7 years), 93 (3%) reported that they had CKD by history, while 306 (10%) had an eGFR < 60 mL/min/1.73m2 persisted for over 3 months. The prevalence of hyperlipidemia, body mass index, waist circumference, leukocyte count, and the incidence of fall differed only between those with and without eGFR-based CKD, but not between those with and without self-reported CKD. A synergistic effect was found between self-reported and eGFR-based CKD regarding the CKD complication severity, including malnutrition (albumin), anemia (hemoglobin), dyslipidemia (serum cholesterol), and geriatric syndromes (cognitive and quality of life impairment). Multivariate regression analyses showed that self-reported CKD exhibited better predictive efficacy for lower serum albumin and hemoglobin than eGFR-based CKD, while the latter outperformed the former for predicting lower serum cholesterol and a higher risk of cognitive impairment. Conclusion: Among older adults, self-reported CKD may not be a surrogate for laboratory-diagnosed CKD and has an independent effect on CKD-related complications. |
| first_indexed | 2024-04-12T03:51:26Z |
| format | Article |
| id | doaj.art-0f2c55c5753d4510b5b1d1115bebe859 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-04-12T03:51:26Z |
| publishDate | 2018-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-0f2c55c5753d4510b5b1d1115bebe8592022-12-22T03:48:58ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432018-12-014361908191810.1159/000496002496002Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older AdultsChia-Ter ChaoYi-Hsuan LeeKuen-Cheh YangJen-Kuei PengChia-Ming LiShih-I ChenDer-Sheng HanJenq-Wen HuangCOGENT study groupBackground/Aims: Awareness of chronic kidney disease (CKD) has been low among affected patients, particularly the older ones. However, whether such awareness is synonymous with the presence of laboratory-diagnosed CKD among older adults is currently unclear. Methods: We enrolled community-dwelling old adults (≥ 65 years) who received health examinations between 2013 and 2016 from a regional metropolitan hospital. Clinical information and geriatric syndromes including depression, cognitive impairment, fall, quality of life, and visual disturbance were evaluated during the medical interview. We compared the differences in clinical features between those with and without self-reported or estimated glomerular filtration rate (eGFR)-based CKD and investigated their influences and interactions on the risk of CKD complications and geriatric syndromes. Results: Among the 2932 enrolled older adults (mean 73.4 ± 7 years), 93 (3%) reported that they had CKD by history, while 306 (10%) had an eGFR < 60 mL/min/1.73m2 persisted for over 3 months. The prevalence of hyperlipidemia, body mass index, waist circumference, leukocyte count, and the incidence of fall differed only between those with and without eGFR-based CKD, but not between those with and without self-reported CKD. A synergistic effect was found between self-reported and eGFR-based CKD regarding the CKD complication severity, including malnutrition (albumin), anemia (hemoglobin), dyslipidemia (serum cholesterol), and geriatric syndromes (cognitive and quality of life impairment). Multivariate regression analyses showed that self-reported CKD exhibited better predictive efficacy for lower serum albumin and hemoglobin than eGFR-based CKD, while the latter outperformed the former for predicting lower serum cholesterol and a higher risk of cognitive impairment. Conclusion: Among older adults, self-reported CKD may not be a surrogate for laboratory-diagnosed CKD and has an independent effect on CKD-related complications.https://www.karger.com/Article/FullText/496002Chronic kidney diseaseEstimated glomerular filtrate rateGeriatricsGeriatric syndromeHypoalbuminemiaInflammationMalnutrition |
| spellingShingle | Chia-Ter Chao Yi-Hsuan Lee Kuen-Cheh Yang Jen-Kuei Peng Chia-Ming Li Shih-I Chen Der-Sheng Han Jenq-Wen Huang COGENT study group Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults Kidney & Blood Pressure Research Chronic kidney disease Estimated glomerular filtrate rate Geriatrics Geriatric syndrome Hypoalbuminemia Inflammation Malnutrition |
| title | Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults |
| title_full | Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults |
| title_fullStr | Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults |
| title_full_unstemmed | Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults |
| title_short | Impact of Self-Report and eGFR-Based Chronic Kidney Disease on the Risk of Chronic Kidney Disease-Related Complications and Geriatric Syndromes in Community-Dwelling Older Adults |
| title_sort | impact of self report and egfr based chronic kidney disease on the risk of chronic kidney disease related complications and geriatric syndromes in community dwelling older adults |
| topic | Chronic kidney disease Estimated glomerular filtrate rate Geriatrics Geriatric syndrome Hypoalbuminemia Inflammation Malnutrition |
| url | https://www.karger.com/Article/FullText/496002 |
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