Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies
Background: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/11/2351 |
| _version_ | 1797492138234085376 |
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| author | Nathalie Rohmann Liasita Munthe Kristina Schlicht Corinna Geisler Tobias J. Demetrowitsch Corinna Bang Julia Jensen-Kroll Kathrin Türk Petra Bacher Andre Franke Karin Schwarz Dominik M. Schulte Matthias Laudes |
| author_facet | Nathalie Rohmann Liasita Munthe Kristina Schlicht Corinna Geisler Tobias J. Demetrowitsch Corinna Bang Julia Jensen-Kroll Kathrin Türk Petra Bacher Andre Franke Karin Schwarz Dominik M. Schulte Matthias Laudes |
| author_sort | Nathalie Rohmann |
| collection | DOAJ |
| description | Background: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of allergies. Methods: Using cross-sectional data from the German FoCus cohort, <i>n</i> = 385 allergy cases, either hay fever (=type I allergy, <i>n</i> = 183) or contact allergy (=type IV allergy, <i>n</i> = 202) were compared to age- and sex-matched healthy control subjects (1:1 ratio, in total <i>n</i> = 770) regarding their metabolic phenotype, diet, physical activity, sleep, gut microbial composition, and serum metabolite profile using suitable BMI-adjusted models. Results: Obesity and metabolic alterations were found significantly more prevalent in subjects with allergies. In fact, this relation was more pronounced in contact allergy than hay fever. Subsequent BMI-adjusted analysis reveals particular importance of co-occurring hyperlipidaemia for both allergy types. For contact allergy, we revealed a strong association to the dietary intake of poly-unsaturated fatty acids, particularly α-linolenic acid, as well as the enrichment of the corresponding metabolic pathway. For hay fever, there were no major associations to the diet but to a lower physical activity level, shorter duration of sleep, and an altered gut microbial composition. Finally, genetic predisposition for hyperlipidaemia was associated to both contact allergy and hay fever. Conclusions: Reflected by higher allergy prevalence, our findings indicate an impaired immune response in obesity and hyperlipidaemia, which is differentially regulated in type I and type IV allergies by an unfavourable lifestyle constellation and subsequent microbial and metabolic dysfunctions. |
| first_indexed | 2024-03-10T00:59:18Z |
| format | Article |
| id | doaj.art-0f31a50553f94cabb79bdc263ad6bd2b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:59:18Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0f31a50553f94cabb79bdc263ad6bd2b2023-11-23T14:37:40ZengMDPI AGNutrients2072-66432022-06-011411235110.3390/nu14112351Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV AllergiesNathalie Rohmann0Liasita Munthe1Kristina Schlicht2Corinna Geisler3Tobias J. Demetrowitsch4Corinna Bang5Julia Jensen-Kroll6Kathrin Türk7Petra Bacher8Andre Franke9Karin Schwarz10Dominik M. Schulte11Matthias Laudes12Institute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDivision of Food Technology, Department of Human Nutrition, Kiel University, 24105 Kiel, GermanyInstitute of Clinical Molecular Biology, Kiel University, 24105 Kiel, GermanyDivision of Food Technology, Department of Human Nutrition, Kiel University, 24105 Kiel, GermanyInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyInstitute of Clinical Molecular Biology, Kiel University, 24105 Kiel, GermanyInstitute of Clinical Molecular Biology, Kiel University, 24105 Kiel, GermanyDivision of Food Technology, Department of Human Nutrition, Kiel University, 24105 Kiel, GermanyInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyBackground: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of allergies. Methods: Using cross-sectional data from the German FoCus cohort, <i>n</i> = 385 allergy cases, either hay fever (=type I allergy, <i>n</i> = 183) or contact allergy (=type IV allergy, <i>n</i> = 202) were compared to age- and sex-matched healthy control subjects (1:1 ratio, in total <i>n</i> = 770) regarding their metabolic phenotype, diet, physical activity, sleep, gut microbial composition, and serum metabolite profile using suitable BMI-adjusted models. Results: Obesity and metabolic alterations were found significantly more prevalent in subjects with allergies. In fact, this relation was more pronounced in contact allergy than hay fever. Subsequent BMI-adjusted analysis reveals particular importance of co-occurring hyperlipidaemia for both allergy types. For contact allergy, we revealed a strong association to the dietary intake of poly-unsaturated fatty acids, particularly α-linolenic acid, as well as the enrichment of the corresponding metabolic pathway. For hay fever, there were no major associations to the diet but to a lower physical activity level, shorter duration of sleep, and an altered gut microbial composition. Finally, genetic predisposition for hyperlipidaemia was associated to both contact allergy and hay fever. Conclusions: Reflected by higher allergy prevalence, our findings indicate an impaired immune response in obesity and hyperlipidaemia, which is differentially regulated in type I and type IV allergies by an unfavourable lifestyle constellation and subsequent microbial and metabolic dysfunctions.https://www.mdpi.com/2072-6643/14/11/2351allergyobesityhyperlipidaemiadiet and lifestyle |
| spellingShingle | Nathalie Rohmann Liasita Munthe Kristina Schlicht Corinna Geisler Tobias J. Demetrowitsch Corinna Bang Julia Jensen-Kroll Kathrin Türk Petra Bacher Andre Franke Karin Schwarz Dominik M. Schulte Matthias Laudes Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies Nutrients allergy obesity hyperlipidaemia diet and lifestyle |
| title | Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies |
| title_full | Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies |
| title_fullStr | Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies |
| title_full_unstemmed | Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies |
| title_short | Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies |
| title_sort | differential effects of obesity hyperlipidaemia dietary intake and physical inactivity on type i versus type iv allergies |
| topic | allergy obesity hyperlipidaemia diet and lifestyle |
| url | https://www.mdpi.com/2072-6643/14/11/2351 |
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