THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME
Aim. To examine relations between hyperinsulinemia, insulin resistance (IR), components of metabolic syndrome (MS) and predisposition to renal damage. Material and methods. A total of 94 MS patients (64 males and 30 females, age 30-67 years, mean age 52±9 years) entered the study. The examination in...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2012-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31042 |
| _version_ | 1828877616023601152 |
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| author | I M Kutyrina A A Kryachkova S A Savelieva |
| author_facet | I M Kutyrina A A Kryachkova S A Savelieva |
| author_sort | I M Kutyrina |
| collection | DOAJ |
| description | Aim. To examine relations between hyperinsulinemia, insulin resistance (IR), components of metabolic syndrome (MS) and predisposition to renal damage. Material and methods. A total of 94 MS patients (64 males and 30 females, age 30-67 years, mean age 52±9 years) entered the study. The examination included measurement of waist and hip circumference, body mass index (BMI), HOMA index, estimation of lipids and immunoreactive insulin concentrations. Renal damage was assessed by glomerular filtration rate and urinary excretion of albumin. The patients were divided into groups by IR and BMI. Results. A strong correlation was found between IR markers and lipid metabolism disorders, hemodynamic parameters. Statistics show that IR is an independent unfavourable factor of renal damage in MS patients. Conclusion. IR is an essential component of MS and an independent factor of development of chronic kidney disease in MS patients. |
| first_indexed | 2024-12-13T08:46:20Z |
| format | Article |
| id | doaj.art-0f31cc244a1d491fb5c22bc4c0e547ef |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T08:46:20Z |
| publishDate | 2012-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-0f31cc244a1d491fb5c22bc4c0e547ef2022-12-21T23:53:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422012-06-01846323628058THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROMEI M Kutyrina0A A Kryachkova1S A Savelieva2Research Institute of Uronephrology and Human Reproductive HealthResearch Institute of Uronephrology and Human Reproductive HealthI.M. Sechenov First Moscow Medical UniversityAim. To examine relations between hyperinsulinemia, insulin resistance (IR), components of metabolic syndrome (MS) and predisposition to renal damage. Material and methods. A total of 94 MS patients (64 males and 30 females, age 30-67 years, mean age 52±9 years) entered the study. The examination included measurement of waist and hip circumference, body mass index (BMI), HOMA index, estimation of lipids and immunoreactive insulin concentrations. Renal damage was assessed by glomerular filtration rate and urinary excretion of albumin. The patients were divided into groups by IR and BMI. Results. A strong correlation was found between IR markers and lipid metabolism disorders, hemodynamic parameters. Statistics show that IR is an independent unfavourable factor of renal damage in MS patients. Conclusion. IR is an essential component of MS and an independent factor of development of chronic kidney disease in MS patients.https://ter-arkhiv.ru/0040-3660/article/view/31042chronic kidney diseaseinsulin resistance |
| spellingShingle | I M Kutyrina A A Kryachkova S A Savelieva THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME Терапевтический архив chronic kidney disease insulin resistance |
| title | THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME |
| title_full | THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME |
| title_fullStr | THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME |
| title_full_unstemmed | THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME |
| title_short | THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME |
| title_sort | role of hyperinsulinemia and insulin resistance in development of chronic kidney disease in patients with metabolic syndrome |
| topic | chronic kidney disease insulin resistance |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31042 |
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