Indium-Catalyzed Annulation of o-Acylanilines with Alkoxyheteroarenes: Synthesis of Heteroaryl[b]quinolines and Subsequent Transformation to Cryptolepine Derivatives

Indium-Catalyzed Annulation of o-Acylanilines with Alkoxyheteroarenes: Synthesis of Heteroaryl[b]quinolines and Subsequent Transformation to Cryptolepine Derivatives

We disclose herein the first synthetic method that is capable of offering heteroaryl[b]quinolines (HA[b]Qs) with structural diversity, which include tricyclic and tetracyclic structures with (benzo)thienyl, (benzo)furanyl, and indolyl rings. The target HA[b]Q is addressed by the annulation of o-acyl...

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Bibliographic Details
Main Authors: Kyohei Yonekura, Mika Shinoda, Yuko Yonekura, Teruhisa Tsuchimoto
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Molecules
Subjects:
anti-cancer activity
anti-malarial activity
heteroarenes
indium
Lewis acids
pyridine
one-pot
quindolines
tandem reaction
Online Access:http://www.mdpi.com/1420-3049/23/4/838

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