Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry data
Background and purpose: To evaluate the long-term outcome of accelerated partial breast irradiation utilizing intraoperatively placed applicator-based brachytherapy (ABB) in early-stage breast cancer. Materials and methods: From our prospective registry, 223 patients with pTis-T2, pN0/pN1mic breast...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Clinical and Translational Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630823000642 |
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| author | Haeyoung Kim Tina J. Hieken Feven Abraha James W. Jakub Kimberly S. Corbin Keith M. Furutani Judy C. Boughey Bradley J. Stish Christopher L. Deufel Amy C. Degnim Dean A. Shumway Safia K. Ahmed Mara A. Piltin Nicole P. Sandhu Amy L. Conners Kathryn J. Ruddy Robert W. Mutter Sean S. Park |
| author_facet | Haeyoung Kim Tina J. Hieken Feven Abraha James W. Jakub Kimberly S. Corbin Keith M. Furutani Judy C. Boughey Bradley J. Stish Christopher L. Deufel Amy C. Degnim Dean A. Shumway Safia K. Ahmed Mara A. Piltin Nicole P. Sandhu Amy L. Conners Kathryn J. Ruddy Robert W. Mutter Sean S. Park |
| author_sort | Haeyoung Kim |
| collection | DOAJ |
| description | Background and purpose: To evaluate the long-term outcome of accelerated partial breast irradiation utilizing intraoperatively placed applicator-based brachytherapy (ABB) in early-stage breast cancer. Materials and methods: From our prospective registry, 223 patients with pTis-T2, pN0/pN1mic breast cancer were treated with ABB. The median treatment duration including surgery and ABB was 7 days. The prescribed doses were 32 Gy/8 fx BID (n = 25), 34 Gy/10 fx BID (n = 99), and 21 Gy/3 fx QD (n = 99). Endocrine therapy (ET) adherence was defined as completion of planned ET or ≥ 80% of the follow-up (FU) period. Cumulative incidence of ipsilateral breast tumor recurrence (IBTR) was estimated and influencing factors for IBTR-free survival rate (IBTRFS) were analyzed. Results: 218/223 patients had hormone receptor-positive tumors, including 38 (17.0%) with Tis and 185 (83.0%) with invasive cancer. After a median FU of 63 months, 19 (8.5%) patients had recurrence [17 (7.6%) with an IBTR]. Rates of 5-year IBTRFS and DFS were 92.2% and 91.1%, respectively. The 5-year IBTRFS rates were significantly higher for post-menopausal women (93.6% vs. 66.4%, p = 0.04), BMI < 30 kg/m2 (97.4% vs. 88.1%, p = 0.02), and ET-adherence (97.5% vs. 88.6%, p = 0.02). IBTRFS did not differ with dose regimens. Conclusions: Postmenopausal status, BMI < 30 kg/m2, and ET- adherence predicted favorable IBTRFS. Our results highlight the importance of careful patient selection for ABB and encouragement of ET compliance. |
| first_indexed | 2024-03-13T02:56:11Z |
| format | Article |
| id | doaj.art-0f34b72eae2b49d190cb40579d87c058 |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-03-13T02:56:11Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-0f34b72eae2b49d190cb40579d87c0582023-06-28T04:29:51ZengElsevierClinical and Translational Radiation Oncology2405-63082023-07-0141100639Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry dataHaeyoung Kim0Tina J. Hieken1Feven Abraha2James W. Jakub3Kimberly S. Corbin4Keith M. Furutani5Judy C. Boughey6Bradley J. Stish7Christopher L. Deufel8Amy C. Degnim9Dean A. Shumway10Safia K. Ahmed11Mara A. Piltin12Nicole P. Sandhu13Amy L. Conners14Kathryn J. Ruddy15Robert W. Mutter16Sean S. Park17Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA; Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University of School of Medicine, Seoul, South KoreaDepartment of Surgery, Mayo Clinic, Rochester, MN, USADepartment of Biostatistics and Health Sciences Research, Mayo Clinic, Rochester, MN, USADepartment of Surgery, Mayo Clinic, Jacksonville, FL, USADepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USADepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USADepartment of Surgery, Mayo Clinic, Rochester, MN, USADepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USADepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USADepartment of Surgery, Mayo Clinic, Rochester, MN, USADepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USADepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USADepartment of Internal Medicine, Mayo Clinic, Rochester, MN, USADepartment of Internal Medicine, Mayo Clinic, Rochester, MN, USADepartment of Radiology, Mayo Clinic, Rochester, MN, USADepartment of Medical Oncology, Mayo Clinic, Rochester, MN, USADepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA; Corresponding authors.Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA; Corresponding authors.Background and purpose: To evaluate the long-term outcome of accelerated partial breast irradiation utilizing intraoperatively placed applicator-based brachytherapy (ABB) in early-stage breast cancer. Materials and methods: From our prospective registry, 223 patients with pTis-T2, pN0/pN1mic breast cancer were treated with ABB. The median treatment duration including surgery and ABB was 7 days. The prescribed doses were 32 Gy/8 fx BID (n = 25), 34 Gy/10 fx BID (n = 99), and 21 Gy/3 fx QD (n = 99). Endocrine therapy (ET) adherence was defined as completion of planned ET or ≥ 80% of the follow-up (FU) period. Cumulative incidence of ipsilateral breast tumor recurrence (IBTR) was estimated and influencing factors for IBTR-free survival rate (IBTRFS) were analyzed. Results: 218/223 patients had hormone receptor-positive tumors, including 38 (17.0%) with Tis and 185 (83.0%) with invasive cancer. After a median FU of 63 months, 19 (8.5%) patients had recurrence [17 (7.6%) with an IBTR]. Rates of 5-year IBTRFS and DFS were 92.2% and 91.1%, respectively. The 5-year IBTRFS rates were significantly higher for post-menopausal women (93.6% vs. 66.4%, p = 0.04), BMI < 30 kg/m2 (97.4% vs. 88.1%, p = 0.02), and ET-adherence (97.5% vs. 88.6%, p = 0.02). IBTRFS did not differ with dose regimens. Conclusions: Postmenopausal status, BMI < 30 kg/m2, and ET- adherence predicted favorable IBTRFS. Our results highlight the importance of careful patient selection for ABB and encouragement of ET compliance.http://www.sciencedirect.com/science/article/pii/S2405630823000642Breast neoplasmsRadiotherapyBrachytherapyBreast-conserving surgeryAccelerated partial breast irradiation |
| spellingShingle | Haeyoung Kim Tina J. Hieken Feven Abraha James W. Jakub Kimberly S. Corbin Keith M. Furutani Judy C. Boughey Bradley J. Stish Christopher L. Deufel Amy C. Degnim Dean A. Shumway Safia K. Ahmed Mara A. Piltin Nicole P. Sandhu Amy L. Conners Kathryn J. Ruddy Robert W. Mutter Sean S. Park Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry data Clinical and Translational Radiation Oncology Breast neoplasms Radiotherapy Brachytherapy Breast-conserving surgery Accelerated partial breast irradiation |
| title | Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry data |
| title_full | Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry data |
| title_fullStr | Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry data |
| title_full_unstemmed | Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry data |
| title_short | Long-term outcomes of intraoperatively-placed applicator brachytherapy for rapid completion of breast conserving treatment: An analysis of a prospective registry data |
| title_sort | long term outcomes of intraoperatively placed applicator brachytherapy for rapid completion of breast conserving treatment an analysis of a prospective registry data |
| topic | Breast neoplasms Radiotherapy Brachytherapy Breast-conserving surgery Accelerated partial breast irradiation |
| url | http://www.sciencedirect.com/science/article/pii/S2405630823000642 |
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