A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family
Zongwei Zhang, Hainan Wen, Hui Wang, Pan Zhang, Jing Li, Yueyi Liang, Yanchao Liu, Lihong Sun, Shoujun Xie Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of ChinaCorrespondence: Shoujun Xie, Department of Clinical L...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/a-case-of-meningitis-in-an-infant-due-to-hypervirulent-klebsiella-pneu-peer-reviewed-fulltext-article-IDR |
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| author | Zhang Z Wen H Wang H Zhang P Li J Liang Y Liu Y Sun L Xie S |
| author_facet | Zhang Z Wen H Wang H Zhang P Li J Liang Y Liu Y Sun L Xie S |
| author_sort | Zhang Z |
| collection | DOAJ |
| description | Zongwei Zhang, Hainan Wen, Hui Wang, Pan Zhang, Jing Li, Yueyi Liang, Yanchao Liu, Lihong Sun, Shoujun Xie Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of ChinaCorrespondence: Shoujun Xie, Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of China, Tel +86 15633142883, Email shoujunxie69@163.comAbstract: Hypervirulent Klebsiella pneumoniae (hvKP), an emerging pathotype derived from K. pneumoniae, frequently causes invasive infections of multiple organs and is associated with both high disability and fatality rates. In this study, a case of meningitis in a young infant caused by hvKP is presented. Cytological and biochemical examinations of the cerebrospinal fluid (CSF) revealed purulent meningitis, a diagnosis that was confirmed by a positive CSF culture result. The pathogen was identified as hvKP through analysis of positive virulence-associated genes. Meanwhile, hvKP was also isolated from stool samples of both the infant and her father. Antimicrobial susceptibility, capsular typing, and multilocus sequence typing (MLST) of three isolates from the infant’s CSF and stool and her father’s stool samples were analyzed. The three K. pneumoniae isolates were susceptible to all antibiotics except ampicillin and were identified as capsular serotype K2 and sequence type 86. These genetic relatedness analyses indicated that the strain isolated from the infant’s CSF might have originated from her father’s stool via familial transmission. This case is the first report of meningitis in an infant due to hvKP transmitted within a family.Keywords: hvKP, purulent meningitis, infant, familial transmission |
| first_indexed | 2024-04-12T23:44:25Z |
| format | Article |
| id | doaj.art-0f35c9b87fe642f099422c0b9a0a96fa |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-12T23:44:25Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-0f35c9b87fe642f099422c0b9a0a96fa2022-12-22T03:11:53ZengDove Medical PressInfection and Drug Resistance1178-69732022-08-01Volume 154927493377741A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a FamilyZhang ZWen HWang HZhang PLi JLiang YLiu YSun LXie SZongwei Zhang, Hainan Wen, Hui Wang, Pan Zhang, Jing Li, Yueyi Liang, Yanchao Liu, Lihong Sun, Shoujun Xie Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of ChinaCorrespondence: Shoujun Xie, Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of China, Tel +86 15633142883, Email shoujunxie69@163.comAbstract: Hypervirulent Klebsiella pneumoniae (hvKP), an emerging pathotype derived from K. pneumoniae, frequently causes invasive infections of multiple organs and is associated with both high disability and fatality rates. In this study, a case of meningitis in a young infant caused by hvKP is presented. Cytological and biochemical examinations of the cerebrospinal fluid (CSF) revealed purulent meningitis, a diagnosis that was confirmed by a positive CSF culture result. The pathogen was identified as hvKP through analysis of positive virulence-associated genes. Meanwhile, hvKP was also isolated from stool samples of both the infant and her father. Antimicrobial susceptibility, capsular typing, and multilocus sequence typing (MLST) of three isolates from the infant’s CSF and stool and her father’s stool samples were analyzed. The three K. pneumoniae isolates were susceptible to all antibiotics except ampicillin and were identified as capsular serotype K2 and sequence type 86. These genetic relatedness analyses indicated that the strain isolated from the infant’s CSF might have originated from her father’s stool via familial transmission. This case is the first report of meningitis in an infant due to hvKP transmitted within a family.Keywords: hvKP, purulent meningitis, infant, familial transmissionhttps://www.dovepress.com/a-case-of-meningitis-in-an-infant-due-to-hypervirulent-klebsiella-pneu-peer-reviewed-fulltext-article-IDRhvkppurulent meningitisinfantfamilial transmission |
| spellingShingle | Zhang Z Wen H Wang H Zhang P Li J Liang Y Liu Y Sun L Xie S A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family Infection and Drug Resistance hvkp purulent meningitis infant familial transmission |
| title | A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family |
| title_full | A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family |
| title_fullStr | A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family |
| title_full_unstemmed | A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family |
| title_short | A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family |
| title_sort | case of meningitis in an infant due to hypervirulent klebsiella pneumoniae transmission within a family |
| topic | hvkp purulent meningitis infant familial transmission |
| url | https://www.dovepress.com/a-case-of-meningitis-in-an-infant-due-to-hypervirulent-klebsiella-pneu-peer-reviewed-fulltext-article-IDR |
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