Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy
The sleep EEG mirrors neuronal connectivity, especially during development when the brain undergoes substantial rewiring. As children grow, the slow-wave activity (SWA; 0.75–4.25 Hz) spatial distribution in their sleep EEG changes along a posterior-to-anterior gradient. Topographical SWA markers hav...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Neurobiology of Sleep and Circadian Rhythms |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245199442300010X |
| _version_ | 1797582916175265792 |
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| author | Matthieu Beaugrand Valeria Jaramillo Andjela Markovic Reto Huber Malcolm Kohler Sarah F. Schoch Salome Kurth |
| author_facet | Matthieu Beaugrand Valeria Jaramillo Andjela Markovic Reto Huber Malcolm Kohler Sarah F. Schoch Salome Kurth |
| author_sort | Matthieu Beaugrand |
| collection | DOAJ |
| description | The sleep EEG mirrors neuronal connectivity, especially during development when the brain undergoes substantial rewiring. As children grow, the slow-wave activity (SWA; 0.75–4.25 Hz) spatial distribution in their sleep EEG changes along a posterior-to-anterior gradient. Topographical SWA markers have been linked to critical neurobehavioral functions, such as motor skills, in school-aged children. However, the relationship between topographical markers in infancy and later behavioral outcomes is still unclear. This study aims to explore reliable indicators of neurodevelopment in infants by analyzing their sleep EEG patterns. Thirty-one 6-month-old infants (15 female) underwent high-density EEG recordings during nighttime sleep. We defined markers based on the topographical distribution of SWA and theta activity, including central/occipital and frontal/occipital ratios and an index derived from local EEG power variability. Linear models were applied to test whether markers relate to concurrent, later, or retrospective behavioral scores, assessed by the parent-reported Ages & Stages Questionnaire at ages 3, 6, 12, and 24 months. Results indicate that the topographical markers of the sleep EEG power in infants were not significantly linked to behavioral development at any age. Further research, such as longitudinal sleep EEG in newborns, is needed to better understand the relationship between these markers and behavioral development and assess their predictive value for individual differences. |
| first_indexed | 2024-03-10T23:29:22Z |
| format | Article |
| id | doaj.art-0f38735e78964c7697ebc1508ffc4cc5 |
| institution | Directory Open Access Journal |
| issn | 2451-9944 |
| language | English |
| last_indexed | 2024-03-10T23:29:22Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Sleep and Circadian Rhythms |
| spelling | doaj.art-0f38735e78964c7697ebc1508ffc4cc52023-11-19T04:35:17ZengElsevierNeurobiology of Sleep and Circadian Rhythms2451-99442023-11-0115100098Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancyMatthieu Beaugrand0Valeria Jaramillo1Andjela Markovic2Reto Huber3Malcolm Kohler4Sarah F. Schoch5Salome Kurth6University of Fribourg, Department of Psychology, Fribourg, SwitzerlandUniversity of Surrey, School of Psychology, Guildford, United KingdomUniversity of Fribourg, Department of Psychology, Fribourg, Switzerland; University Hospital Zurich, Department of Pulmonology, Zurich, SwitzerlandCenter of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, SwitzerlandUniversity Hospital Zurich, Department of Pulmonology, Zurich, Switzerland; Center of Competence Sleep & Health Zurich, University of Zurich, Zurich, SwitzerlandUniversity Hospital Zurich, Department of Pulmonology, Zurich, Switzerland; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the NetherlandsUniversity of Fribourg, Department of Psychology, Fribourg, Switzerland; Corresponding author.The sleep EEG mirrors neuronal connectivity, especially during development when the brain undergoes substantial rewiring. As children grow, the slow-wave activity (SWA; 0.75–4.25 Hz) spatial distribution in their sleep EEG changes along a posterior-to-anterior gradient. Topographical SWA markers have been linked to critical neurobehavioral functions, such as motor skills, in school-aged children. However, the relationship between topographical markers in infancy and later behavioral outcomes is still unclear. This study aims to explore reliable indicators of neurodevelopment in infants by analyzing their sleep EEG patterns. Thirty-one 6-month-old infants (15 female) underwent high-density EEG recordings during nighttime sleep. We defined markers based on the topographical distribution of SWA and theta activity, including central/occipital and frontal/occipital ratios and an index derived from local EEG power variability. Linear models were applied to test whether markers relate to concurrent, later, or retrospective behavioral scores, assessed by the parent-reported Ages & Stages Questionnaire at ages 3, 6, 12, and 24 months. Results indicate that the topographical markers of the sleep EEG power in infants were not significantly linked to behavioral development at any age. Further research, such as longitudinal sleep EEG in newborns, is needed to better understand the relationship between these markers and behavioral development and assess their predictive value for individual differences.http://www.sciencedirect.com/science/article/pii/S245199442300010XHigh-density EEGBiomarkersNeuronal ConnectivityNewbornsIndividual differencesBehavioural outcomes |
| spellingShingle | Matthieu Beaugrand Valeria Jaramillo Andjela Markovic Reto Huber Malcolm Kohler Sarah F. Schoch Salome Kurth Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy Neurobiology of Sleep and Circadian Rhythms High-density EEG Biomarkers Neuronal Connectivity Newborns Individual differences Behavioural outcomes |
| title | Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy |
| title_full | Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy |
| title_fullStr | Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy |
| title_full_unstemmed | Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy |
| title_short | Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy |
| title_sort | lack of association between behavioral development and simplified topographical markers of the sleep eeg in infancy |
| topic | High-density EEG Biomarkers Neuronal Connectivity Newborns Individual differences Behavioural outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S245199442300010X |
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