The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review
Currently, the antioxidant properties of amino acids and their role in the physicochemical processes accompanying oxidative stress in cancer remain unclear. Cancer cells are known to extensively uptake amino acids, which are used as an energy source, antioxidant precursors that reduce oxidative stre...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/14/1/28 |
| _version_ | 1797339592684208128 |
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| author | Elena I. Dyachenko Lyudmila V. Bel’skaya |
| author_facet | Elena I. Dyachenko Lyudmila V. Bel’skaya |
| author_sort | Elena I. Dyachenko |
| collection | DOAJ |
| description | Currently, the antioxidant properties of amino acids and their role in the physicochemical processes accompanying oxidative stress in cancer remain unclear. Cancer cells are known to extensively uptake amino acids, which are used as an energy source, antioxidant precursors that reduce oxidative stress in cancer, and as regulators of inhibiting or inducing tumor cell-associated gene expression. This review examines nine amino acids (Cys, His, Phe, Met, Trp, Tyr, Pro, Arg, Lys), which play a key role in the non-enzymatic oxidative process in various cancers. Conventionally, these amino acids can be divided into two groups, in one of which the activity increases (Cys, Phe, Met, Pro, Arg, Lys) in cancer, and in the other, it decreases (His, Trp, Tyr). The review examines changes in the metabolism of nine amino acids in eleven types of oncology. We have identified the main nonspecific mechanisms of changes in the metabolic activity of amino acids, and described direct and indirect effects on the redox homeostasis of cells. In the future, this will help to understand better the nature of life of a cancer cell and identify therapeutic targets more effectively. |
| first_indexed | 2024-03-08T09:50:28Z |
| format | Article |
| id | doaj.art-0f38a4d4f5c843d6afac93724e330b3f |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-08T09:50:28Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-0f38a4d4f5c843d6afac93724e330b3f2024-01-29T14:04:46ZengMDPI AGMetabolites2218-19892023-12-011412810.3390/metabo14010028The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A ReviewElena I. Dyachenko0Lyudmila V. Bel’skaya1Biochemistry Research Laboratory, Omsk State Pedagogical University, Omsk 644099, RussiaBiochemistry Research Laboratory, Omsk State Pedagogical University, Omsk 644099, RussiaCurrently, the antioxidant properties of amino acids and their role in the physicochemical processes accompanying oxidative stress in cancer remain unclear. Cancer cells are known to extensively uptake amino acids, which are used as an energy source, antioxidant precursors that reduce oxidative stress in cancer, and as regulators of inhibiting or inducing tumor cell-associated gene expression. This review examines nine amino acids (Cys, His, Phe, Met, Trp, Tyr, Pro, Arg, Lys), which play a key role in the non-enzymatic oxidative process in various cancers. Conventionally, these amino acids can be divided into two groups, in one of which the activity increases (Cys, Phe, Met, Pro, Arg, Lys) in cancer, and in the other, it decreases (His, Trp, Tyr). The review examines changes in the metabolism of nine amino acids in eleven types of oncology. We have identified the main nonspecific mechanisms of changes in the metabolic activity of amino acids, and described direct and indirect effects on the redox homeostasis of cells. In the future, this will help to understand better the nature of life of a cancer cell and identify therapeutic targets more effectively.https://www.mdpi.com/2218-1989/14/1/28amino acidscanceroxidative stressnon-enzymatic antioxidant system |
| spellingShingle | Elena I. Dyachenko Lyudmila V. Bel’skaya The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review Metabolites amino acids cancer oxidative stress non-enzymatic antioxidant system |
| title | The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review |
| title_full | The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review |
| title_fullStr | The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review |
| title_full_unstemmed | The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review |
| title_short | The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review |
| title_sort | role of amino acids in non enzymatic antioxidant mechanisms in cancer a review |
| topic | amino acids cancer oxidative stress non-enzymatic antioxidant system |
| url | https://www.mdpi.com/2218-1989/14/1/28 |
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