Exosomal microRNA-Based therapies for skin diseases
Based on engineered cell/exosome technology and various skin-related animal models, exosomal microRNA (miRNA)-based therapies derived from natural exosomes have shown good therapeutic effects on nine skin diseases, including full-thickness skin defects, diabetic ulcers, skin burns, hypertrophic scar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320423001384 |
| _version_ | 1827323126090825728 |
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| author | Chen Jibing Liang Weiping Yang Yuwei Feng Bingzheng Xu Zhiran |
| author_facet | Chen Jibing Liang Weiping Yang Yuwei Feng Bingzheng Xu Zhiran |
| author_sort | Chen Jibing |
| collection | DOAJ |
| description | Based on engineered cell/exosome technology and various skin-related animal models, exosomal microRNA (miRNA)-based therapies derived from natural exosomes have shown good therapeutic effects on nine skin diseases, including full-thickness skin defects, diabetic ulcers, skin burns, hypertrophic scars, psoriasis, systemic sclerosis, atopic dermatitis, skin aging, and hair loss. Comparative experimental research showed that the therapeutic effect of miRNA-overexpressing exosomes was better than that of their natural exosomes. Using a dual-luciferase reporter assay, the targets of all therapeutic miRNAs in skin cells have been screened and confirmed. For these nine types of skin diseases, a total of 11 animal models and 21 exosomal miRNA-based therapies have been developed. This review provides a detailed description of the animal models, miRNA therapies, disease evaluation indicators, and treatment results of exosomal miRNA therapies, with the aim of providing a reference and guidance for future clinical trials. There is currently no literature on the merits or drawbacks of miRNA therapies compared with standard treatments. |
| first_indexed | 2024-03-08T19:58:47Z |
| format | Article |
| id | doaj.art-0f395ebe9535401199ab88d8aeece96e |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-25T01:40:42Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-0f395ebe9535401199ab88d8aeece96e2024-03-08T05:18:47ZengElsevierRegenerative Therapy2352-32042024-03-0125101112Exosomal microRNA-Based therapies for skin diseasesChen Jibing0Liang Weiping1Yang Yuwei2Feng Bingzheng3Xu Zhiran4Corresponding author.; Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaRuikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaRuikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaRuikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaRuikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaBased on engineered cell/exosome technology and various skin-related animal models, exosomal microRNA (miRNA)-based therapies derived from natural exosomes have shown good therapeutic effects on nine skin diseases, including full-thickness skin defects, diabetic ulcers, skin burns, hypertrophic scars, psoriasis, systemic sclerosis, atopic dermatitis, skin aging, and hair loss. Comparative experimental research showed that the therapeutic effect of miRNA-overexpressing exosomes was better than that of their natural exosomes. Using a dual-luciferase reporter assay, the targets of all therapeutic miRNAs in skin cells have been screened and confirmed. For these nine types of skin diseases, a total of 11 animal models and 21 exosomal miRNA-based therapies have been developed. This review provides a detailed description of the animal models, miRNA therapies, disease evaluation indicators, and treatment results of exosomal miRNA therapies, with the aim of providing a reference and guidance for future clinical trials. There is currently no literature on the merits or drawbacks of miRNA therapies compared with standard treatments.http://www.sciencedirect.com/science/article/pii/S2352320423001384ExosomemicroRNAMesenchymal stem cellSkin diseaseSkin aging |
| spellingShingle | Chen Jibing Liang Weiping Yang Yuwei Feng Bingzheng Xu Zhiran Exosomal microRNA-Based therapies for skin diseases Regenerative Therapy Exosome microRNA Mesenchymal stem cell Skin disease Skin aging |
| title | Exosomal microRNA-Based therapies for skin diseases |
| title_full | Exosomal microRNA-Based therapies for skin diseases |
| title_fullStr | Exosomal microRNA-Based therapies for skin diseases |
| title_full_unstemmed | Exosomal microRNA-Based therapies for skin diseases |
| title_short | Exosomal microRNA-Based therapies for skin diseases |
| title_sort | exosomal microrna based therapies for skin diseases |
| topic | Exosome microRNA Mesenchymal stem cell Skin disease Skin aging |
| url | http://www.sciencedirect.com/science/article/pii/S2352320423001384 |
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