Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction?
<p>Abstract</p> <p>Background</p> <p>The optimum protocol for expander volume adjustment with respect to the timing and application of radiotherapy remains controversial.</p> <p>Methods</p> <p>Eighteen New Zealand rabbits were divided into three...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-02-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/44 |
| _version_ | 1811260146221842432 |
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| author | Celet Ozden Burcu Guven Erdem Aslay Isik Kemikler Gonul Olgac Vakur Soluk Tekkesin Merva Serarslan Bengul Tumerdem Ulug Burcak Bilgin Karabulut Aylin Arinci Atilla Emekli Ufuk |
| author_facet | Celet Ozden Burcu Guven Erdem Aslay Isik Kemikler Gonul Olgac Vakur Soluk Tekkesin Merva Serarslan Bengul Tumerdem Ulug Burcak Bilgin Karabulut Aylin Arinci Atilla Emekli Ufuk |
| author_sort | Celet Ozden Burcu |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The optimum protocol for expander volume adjustment with respect to the timing and application of radiotherapy remains controversial.</p> <p>Methods</p> <p>Eighteen New Zealand rabbits were divided into three groups. Metallic port integrated anatomic breast expanders of 250 cc were implanted on the back of each animal and controlled expansion was performed. Group I underwent radiotherapy with full expanders while in Group II, expanders were partially deflated immediately prior to radiotherapy. Control group did not receive radiotherapy.</p> <p>The changes in blood flow at different volume adjustments were investigated in Group II by laser Doppler flowmetry. Variations in the histopathologic properties of the irradiated tissues including the skin, capsule and the pocket floor, were compared in the biopsy specimens taken from different locations in each group.</p> <p>Results</p> <p>A significant increase in skin blood flow was detected in Group II with partial expander deflation. Overall, histopathologic exam revealed aggravated findings of chronic radiodermatitis (epidermal atrophy, dermal inflammation and fibrosis, neovascularisation and vascular changes as well as increased capsule thickness) especially around the lower expander pole, in Group II.</p> <p>Conclusions</p> <p>Expander deflation immediately prior to radiotherapy, may augment the adverse effects, especially in the lower expander pole, possibly via enhanced radiosensitization due to a relative increase in the blood flow and tissue oxygenation.</p> |
| first_indexed | 2024-04-12T18:43:04Z |
| format | Article |
| id | doaj.art-0f3ab8856ba14f8d9430db0a1eb1b315 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-12T18:43:04Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-0f3ab8856ba14f8d9430db0a1eb1b3152022-12-22T03:20:42ZengBMCWorld Journal of Surgical Oncology1477-78192012-02-011014410.1186/1477-7819-10-44Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction?Celet Ozden BurcuGuven ErdemAslay IsikKemikler GonulOlgac VakurSoluk Tekkesin MervaSerarslan BengulTumerdem Ulug BurcakBilgin Karabulut AylinArinci AtillaEmekli Ufuk<p>Abstract</p> <p>Background</p> <p>The optimum protocol for expander volume adjustment with respect to the timing and application of radiotherapy remains controversial.</p> <p>Methods</p> <p>Eighteen New Zealand rabbits were divided into three groups. Metallic port integrated anatomic breast expanders of 250 cc were implanted on the back of each animal and controlled expansion was performed. Group I underwent radiotherapy with full expanders while in Group II, expanders were partially deflated immediately prior to radiotherapy. Control group did not receive radiotherapy.</p> <p>The changes in blood flow at different volume adjustments were investigated in Group II by laser Doppler flowmetry. Variations in the histopathologic properties of the irradiated tissues including the skin, capsule and the pocket floor, were compared in the biopsy specimens taken from different locations in each group.</p> <p>Results</p> <p>A significant increase in skin blood flow was detected in Group II with partial expander deflation. Overall, histopathologic exam revealed aggravated findings of chronic radiodermatitis (epidermal atrophy, dermal inflammation and fibrosis, neovascularisation and vascular changes as well as increased capsule thickness) especially around the lower expander pole, in Group II.</p> <p>Conclusions</p> <p>Expander deflation immediately prior to radiotherapy, may augment the adverse effects, especially in the lower expander pole, possibly via enhanced radiosensitization due to a relative increase in the blood flow and tissue oxygenation.</p>http://www.wjso.com/content/10/1/44Two-stage breast reconstructionRadiotherapyTissue expansion |
| spellingShingle | Celet Ozden Burcu Guven Erdem Aslay Isik Kemikler Gonul Olgac Vakur Soluk Tekkesin Merva Serarslan Bengul Tumerdem Ulug Burcak Bilgin Karabulut Aylin Arinci Atilla Emekli Ufuk Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction? World Journal of Surgical Oncology Two-stage breast reconstruction Radiotherapy Tissue expansion |
| title | Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction? |
| title_full | Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction? |
| title_fullStr | Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction? |
| title_full_unstemmed | Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction? |
| title_short | Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction? |
| title_sort | does partial expander deflation exacerbate the adverse effects of radiotherapy in two stage breast reconstruction |
| topic | Two-stage breast reconstruction Radiotherapy Tissue expansion |
| url | http://www.wjso.com/content/10/1/44 |
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