The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy
Background and aims: One of the main potential problems of radiotherapy (RT) in breast cancer is the increase in treatment-related inflammation. This study aimed to investigate the effect of eight weeks of moderate-intensity aerobic training (AT) on serum levels of tumor necrosis factor α (TNF-α) an...
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| Format: | Article |
| Language: | English |
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Shahrekord University of Medical Sciences
2021-12-01
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| Series: | Journal of Shahrekord University of Medical Sciences |
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| Online Access: | http://j.skums.ac.ir/PDF/jskums-23-179.pdf |
| _version_ | 1798027094609887232 |
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| author | Mina Khaleghi Khalid Mohamadzadeh Salamat Mohammad Parastesh Kamal Azizbeigi Mohammad Reza Bayatiani |
| author_facet | Mina Khaleghi Khalid Mohamadzadeh Salamat Mohammad Parastesh Kamal Azizbeigi Mohammad Reza Bayatiani |
| author_sort | Mina Khaleghi |
| collection | DOAJ |
| description | Background and aims: One of the main potential problems of radiotherapy (RT) in breast cancer is the increase in treatment-related inflammation. This study aimed to investigate the effect of eight weeks of moderate-intensity aerobic training (AT) on serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in rats undergoing RT. Materials and Methods: In this experimental study, 32 male rats were randomly divided into four groups of eight members including (1) healthy control (C), (2) AT, (3) RT, and (4) AT + RT groups. Rats were first anesthetized with ketamine-xylazine solution (K, 60-90 kg/mg; Z, 6-10 kg/mg) and then located on a Plexiglas plate with a thickness of 1 cm. Photon beam RT was performed using X-rays with a dose of 11 Gy from an Elekta compact linear accelerator (Elekta Compact 6-MV China). AT program was performed for eight weeks, five days a week, and one session a day for 60 minutes (70-75% of VO2max). Afterwards, one-way ANOVA was run to examine the research variables. Results: According to the results, TNF-α was significantly higher in the RT group compared to the C group (P=0.003), whereas IL-6 levels were significantly lower in the AT + RT group compared to the RT group (P=0.001) and the C group (P=0.027). Further, the levels of this cytokine were significantly lower in the AT group compared to the RT group (P=0.006) and similarly in the RT group compared to the C group (P=0.03). Conclusion: RT led to an increase in pro-inflammatory cytokines; however, performing AT could only significantly reduce the IL-6 levels. |
| first_indexed | 2024-04-11T18:45:54Z |
| format | Article |
| id | doaj.art-0f3cd661c2464e6e809b362921ad60e6 |
| institution | Directory Open Access Journal |
| issn | 2717-0071 |
| language | English |
| last_indexed | 2024-04-11T18:45:54Z |
| publishDate | 2021-12-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of Shahrekord University of Medical Sciences |
| spelling | doaj.art-0f3cd661c2464e6e809b362921ad60e62022-12-22T04:08:46ZengShahrekord University of Medical SciencesJournal of Shahrekord University of Medical Sciences2717-00712021-12-0123417918310.34172/jsums.2021.30jskums-521The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapyMina Khaleghi0Khalid Mohamadzadeh Salamat1Mohammad Parastesh2Kamal Azizbeigi3Mohammad Reza Bayatiani4Department of Exercise Physiology, Islamic Azad University, Sanandj Branch, Sanandaj , IranDepartment of Exercise Physiology, Islamic Azad University, Sanandj Branch, Sanandaj , IranDepartment of Sports Physiology and Pathology, Faculty of Sport Sciences, Arak University, Arak, IranDepartment of Exercise Physiology, Islamic Azad University, Sanandj Branch, Sanandaj , IranDepartment of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari Hospital, Arak, IranBackground and aims: One of the main potential problems of radiotherapy (RT) in breast cancer is the increase in treatment-related inflammation. This study aimed to investigate the effect of eight weeks of moderate-intensity aerobic training (AT) on serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in rats undergoing RT. Materials and Methods: In this experimental study, 32 male rats were randomly divided into four groups of eight members including (1) healthy control (C), (2) AT, (3) RT, and (4) AT + RT groups. Rats were first anesthetized with ketamine-xylazine solution (K, 60-90 kg/mg; Z, 6-10 kg/mg) and then located on a Plexiglas plate with a thickness of 1 cm. Photon beam RT was performed using X-rays with a dose of 11 Gy from an Elekta compact linear accelerator (Elekta Compact 6-MV China). AT program was performed for eight weeks, five days a week, and one session a day for 60 minutes (70-75% of VO2max). Afterwards, one-way ANOVA was run to examine the research variables. Results: According to the results, TNF-α was significantly higher in the RT group compared to the C group (P=0.003), whereas IL-6 levels were significantly lower in the AT + RT group compared to the RT group (P=0.001) and the C group (P=0.027). Further, the levels of this cytokine were significantly lower in the AT group compared to the RT group (P=0.006) and similarly in the RT group compared to the C group (P=0.03). Conclusion: RT led to an increase in pro-inflammatory cytokines; however, performing AT could only significantly reduce the IL-6 levels.http://j.skums.ac.ir/PDF/jskums-23-179.pdfradiotherapyaerobic exercisetnf-αil-6 |
| spellingShingle | Mina Khaleghi Khalid Mohamadzadeh Salamat Mohammad Parastesh Kamal Azizbeigi Mohammad Reza Bayatiani The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy Journal of Shahrekord University of Medical Sciences radiotherapy aerobic exercise tnf-α il-6 |
| title | The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy |
| title_full | The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy |
| title_fullStr | The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy |
| title_full_unstemmed | The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy |
| title_short | The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy |
| title_sort | effect of moderate intensity aerobic training on serum levels of tnf α and il 6 in rats undergoing radiotherapy |
| topic | radiotherapy aerobic exercise tnf-α il-6 |
| url | http://j.skums.ac.ir/PDF/jskums-23-179.pdf |
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