High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

Abstract Background Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for glioma patients. Thus, the development of novel targeted therapeutics for glioma is urgently needed. Methods In this study, we examin...

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Bibliographic Details
Main Authors: Chenglong Yue, Mingshan Niu, Qian Qian Shan, Ting Zhou, Yiming Tu, Peng Xie, Lei Hua, Rutong Yu, Xuejiao Liu
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma
BTK
Ibrutinib
Clinical outcome
NF-κB pathway
Online Access:http://link.springer.com/article/10.1186/s13046-017-0600-7

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