Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy
During the menopausal transition, which begins four to six years before cessation of menses, middle-aged women experience a progressive change in ovarian activity and a physiologic deterioration of hypothalamic-pituitary-ovarian axis function associated with fluctuating hormone levels. During this t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/10/668 |
| _version_ | 1797721248143245312 |
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| author | Giulia Gava Isabella Orsili Stefania Alvisi Ilaria Mancini Renato Seracchioli Maria Cristina Meriggiola |
| author_facet | Giulia Gava Isabella Orsili Stefania Alvisi Ilaria Mancini Renato Seracchioli Maria Cristina Meriggiola |
| author_sort | Giulia Gava |
| collection | DOAJ |
| description | During the menopausal transition, which begins four to six years before cessation of menses, middle-aged women experience a progressive change in ovarian activity and a physiologic deterioration of hypothalamic-pituitary-ovarian axis function associated with fluctuating hormone levels. During this transition, women can suffer symptoms related to menopause (such as hot flushes, sleep disturbance, mood changes, memory complaints and vaginal dryness). Neurological symptoms such as sleep disturbance, “brain fog” and mood changes are a major complaint of women transitioning menopause, with a significant impact on their quality of life, productivity and physical health. In this paper, we consider the associations between menopausal stage and/or hormone levels and sleep problems, mood and reduced cognitive performance. The role of estrogen and menopause hormone therapy (MHT) in cognitive function, sleep and mood are also discussed. |
| first_indexed | 2024-03-12T09:30:51Z |
| format | Article |
| id | doaj.art-0f3fb6bd45a443e5ab8baadc698c7baf |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:30:51Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-0f3fb6bd45a443e5ab8baadc698c7baf2023-09-02T13:54:14ZengMDPI AGMedicina1010-660X2019-10-01551066810.3390/medicina55100668medicina55100668Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone TherapyGiulia Gava0Isabella Orsili1Stefania Alvisi2Ilaria Mancini3Renato Seracchioli4Maria Cristina Meriggiola5Gynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyGynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyGynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyGynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyGynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyGynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyDuring the menopausal transition, which begins four to six years before cessation of menses, middle-aged women experience a progressive change in ovarian activity and a physiologic deterioration of hypothalamic-pituitary-ovarian axis function associated with fluctuating hormone levels. During this transition, women can suffer symptoms related to menopause (such as hot flushes, sleep disturbance, mood changes, memory complaints and vaginal dryness). Neurological symptoms such as sleep disturbance, “brain fog” and mood changes are a major complaint of women transitioning menopause, with a significant impact on their quality of life, productivity and physical health. In this paper, we consider the associations between menopausal stage and/or hormone levels and sleep problems, mood and reduced cognitive performance. The role of estrogen and menopause hormone therapy (MHT) in cognitive function, sleep and mood are also discussed.https://www.mdpi.com/1010-660X/55/10/668menopausehormonesmenopause hormone therapycognitionmoodsleep |
| spellingShingle | Giulia Gava Isabella Orsili Stefania Alvisi Ilaria Mancini Renato Seracchioli Maria Cristina Meriggiola Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy Medicina menopause hormones menopause hormone therapy cognition mood sleep |
| title | Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy |
| title_full | Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy |
| title_fullStr | Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy |
| title_full_unstemmed | Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy |
| title_short | Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy |
| title_sort | cognition mood and sleep in menopausal transition the role of menopause hormone therapy |
| topic | menopause hormones menopause hormone therapy cognition mood sleep |
| url | https://www.mdpi.com/1010-660X/55/10/668 |
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