Real-world data from selective laser trabeculoplasty in Brazil
Abstract Evaluate real-world data of outcomes from selective laser trabeculoplasty (SLT) performed in different regions of Brazil and investigate potential predictors of success associated with treatment. Multicenter retrospective case series with patients who underwent a primary SLT procedure. A to...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-05699-6 |
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| author | Ricardo Y. Abe Heloísa A. Maestrini Guilherme B. Guedes Marcelo M. Nascimento Camila I. Iguma Hérika Danielle de Miranda Santos Muna Georges Nasr Ricarte P. Lucena-Junior Tiago S. Prata |
| author_facet | Ricardo Y. Abe Heloísa A. Maestrini Guilherme B. Guedes Marcelo M. Nascimento Camila I. Iguma Hérika Danielle de Miranda Santos Muna Georges Nasr Ricarte P. Lucena-Junior Tiago S. Prata |
| author_sort | Ricardo Y. Abe |
| collection | DOAJ |
| description | Abstract Evaluate real-world data of outcomes from selective laser trabeculoplasty (SLT) performed in different regions of Brazil and investigate potential predictors of success associated with treatment. Multicenter retrospective case series with patients who underwent a primary SLT procedure. A total of 835 eyes from 835 patients were included. The mean follow-up was 916.8 ± 563.0 days. The mean age was 64.5 ± 14.9 years and 56.6% were women. We observed an intraocular pressure reduction comparing baseline to post-SLT measurements (18.4 ± 3.8 mmHg versus 14.8 ± 3.5 mmHg; P < 0.001) and mean number of glaucoma medications (1.8 ± 1.3 versus 1.4 ± 1.4; P < 0.001). We observed visual acuity loss over time (0.1 ± 0.3 versus 0.2 ± 0.3 logMAR, baseline and post-SLT, respectively, P = 0.009) and decrease in visual field mean deviation values (− 5.4 ± 5.9 versus − 5.7 ± 6.0 dB; P = 0.054) The Kaplan–Meier survival analysis showed an estimated probability of treatment success of 88% at 12 months, declining to 70% at 24 months and 54% at 36 months post-SLT. In the multivariable model, we found that a denser angle pigmentation (HR 0.69; 95% CI 0.57–0.85, P = 0.001) and corticosteroid treatment following SLT (HR 0.59; 95% CI 0.39–0.91, P = 0.018) were significantly associated with a lower risk for failure. Primary SLT achieved relatively high success rates without sight-threating complications in this real-world study with a large sample of Brazilian patients. These findings corroborate previous studies regarding SLT outcomes and may help clinicians to identify the best candidates for laser treatment. |
| first_indexed | 2024-12-10T16:22:20Z |
| format | Article |
| id | doaj.art-0f403e9c01ed4eb1877ef2be126c4acb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-10T16:22:20Z |
| publishDate | 2022-02-01 |
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| spelling | doaj.art-0f403e9c01ed4eb1877ef2be126c4acb2022-12-22T01:41:46ZengNature PortfolioScientific Reports2045-23222022-02-011211810.1038/s41598-022-05699-6Real-world data from selective laser trabeculoplasty in BrazilRicardo Y. Abe0Heloísa A. Maestrini1Guilherme B. Guedes2Marcelo M. Nascimento3Camila I. Iguma4Hérika Danielle de Miranda Santos5Muna Georges Nasr6Ricarte P. Lucena-Junior7Tiago S. Prata8Hospital Oftalmológico de BrasíliaOculare, Hospital de OlhosHospital de Olhos do ParanáClínica GlaukosHospital Oftalmológico de BrasíliaOculare, Hospital de OlhosHospital de Olhos do ParanáHospital Medicina Dos OlhosHospital Medicina Dos OlhosAbstract Evaluate real-world data of outcomes from selective laser trabeculoplasty (SLT) performed in different regions of Brazil and investigate potential predictors of success associated with treatment. Multicenter retrospective case series with patients who underwent a primary SLT procedure. A total of 835 eyes from 835 patients were included. The mean follow-up was 916.8 ± 563.0 days. The mean age was 64.5 ± 14.9 years and 56.6% were women. We observed an intraocular pressure reduction comparing baseline to post-SLT measurements (18.4 ± 3.8 mmHg versus 14.8 ± 3.5 mmHg; P < 0.001) and mean number of glaucoma medications (1.8 ± 1.3 versus 1.4 ± 1.4; P < 0.001). We observed visual acuity loss over time (0.1 ± 0.3 versus 0.2 ± 0.3 logMAR, baseline and post-SLT, respectively, P = 0.009) and decrease in visual field mean deviation values (− 5.4 ± 5.9 versus − 5.7 ± 6.0 dB; P = 0.054) The Kaplan–Meier survival analysis showed an estimated probability of treatment success of 88% at 12 months, declining to 70% at 24 months and 54% at 36 months post-SLT. In the multivariable model, we found that a denser angle pigmentation (HR 0.69; 95% CI 0.57–0.85, P = 0.001) and corticosteroid treatment following SLT (HR 0.59; 95% CI 0.39–0.91, P = 0.018) were significantly associated with a lower risk for failure. Primary SLT achieved relatively high success rates without sight-threating complications in this real-world study with a large sample of Brazilian patients. These findings corroborate previous studies regarding SLT outcomes and may help clinicians to identify the best candidates for laser treatment.https://doi.org/10.1038/s41598-022-05699-6 |
| spellingShingle | Ricardo Y. Abe Heloísa A. Maestrini Guilherme B. Guedes Marcelo M. Nascimento Camila I. Iguma Hérika Danielle de Miranda Santos Muna Georges Nasr Ricarte P. Lucena-Junior Tiago S. Prata Real-world data from selective laser trabeculoplasty in Brazil Scientific Reports |
| title | Real-world data from selective laser trabeculoplasty in Brazil |
| title_full | Real-world data from selective laser trabeculoplasty in Brazil |
| title_fullStr | Real-world data from selective laser trabeculoplasty in Brazil |
| title_full_unstemmed | Real-world data from selective laser trabeculoplasty in Brazil |
| title_short | Real-world data from selective laser trabeculoplasty in Brazil |
| title_sort | real world data from selective laser trabeculoplasty in brazil |
| url | https://doi.org/10.1038/s41598-022-05699-6 |
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