Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010.
The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412995/pdf/?tool=EBI |
| _version_ | 1818401503251005440 |
|---|---|
| author | Fernando González-Candelas Jenaro Astray Jordi Alonso Ady Castro Rafael Cantón Juan Carlos Galán Olatz Garin Marc Sáez Nuria Soldevila Maretva Baricot Jesús Castilla Pere Godoy Miguel Delgado-Rodríguez Vicente Martín José María Mayoral Tomás Pumarola José María Quintana Sonia Tamames Angela Domínguez CIBERESP Cases and Controls in Pandemic Influenza Working Group |
| author_facet | Fernando González-Candelas Jenaro Astray Jordi Alonso Ady Castro Rafael Cantón Juan Carlos Galán Olatz Garin Marc Sáez Nuria Soldevila Maretva Baricot Jesús Castilla Pere Godoy Miguel Delgado-Rodríguez Vicente Martín José María Mayoral Tomás Pumarola José María Quintana Sonia Tamames Angela Domínguez CIBERESP Cases and Controls in Pandemic Influenza Working Group |
| author_sort | Fernando González-Candelas |
| collection | DOAJ |
| description | The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI≥40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population. |
| first_indexed | 2024-12-14T07:53:30Z |
| format | Article |
| id | doaj.art-0f422132d1ea48fe8a33c50074c79214 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T07:53:30Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0f422132d1ea48fe8a33c50074c792142022-12-21T23:10:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3313910.1371/journal.pone.0033139Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010.Fernando González-CandelasJenaro AstrayJordi AlonsoAdy CastroRafael CantónJuan Carlos GalánOlatz GarinMarc SáezNuria SoldevilaMaretva BaricotJesús CastillaPere GodoyMiguel Delgado-RodríguezVicente MartínJosé María MayoralTomás PumarolaJosé María QuintanaSonia TamamesAngela DomínguezCIBERESP Cases and Controls in Pandemic Influenza Working GroupThe emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI≥40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412995/pdf/?tool=EBI |
| spellingShingle | Fernando González-Candelas Jenaro Astray Jordi Alonso Ady Castro Rafael Cantón Juan Carlos Galán Olatz Garin Marc Sáez Nuria Soldevila Maretva Baricot Jesús Castilla Pere Godoy Miguel Delgado-Rodríguez Vicente Martín José María Mayoral Tomás Pumarola José María Quintana Sonia Tamames Angela Domínguez CIBERESP Cases and Controls in Pandemic Influenza Working Group Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010. PLoS ONE |
| title | Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010. |
| title_full | Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010. |
| title_fullStr | Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010. |
| title_full_unstemmed | Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010. |
| title_short | Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010. |
| title_sort | sociodemographic factors and clinical conditions associated to hospitalization in influenza a h1n1 2009 virus infected patients in spain 2009 2010 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412995/pdf/?tool=EBI |
| work_keys_str_mv | AT fernandogonzalezcandelas sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT jenaroastray sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT jordialonso sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT adycastro sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT rafaelcanton sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT juancarlosgalan sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT olatzgarin sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT marcsaez sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT nuriasoldevila sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT maretvabaricot sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT jesuscastilla sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT peregodoy sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT migueldelgadorodriguez sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT vicentemartin sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT josemariamayoral sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT tomaspumarola sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT josemariaquintana sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT soniatamames sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT angeladominguez sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 AT ciberespcasesandcontrolsinpandemicinfluenzaworkinggroup sociodemographicfactorsandclinicalconditionsassociatedtohospitalizationininfluenzaah1n12009virusinfectedpatientsinspain20092010 |