Microglia innately develop within cerebral organoids
Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06684-2 |
| _version_ | 1818420053134016512 |
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| author | Paul R. Ormel Renata Vieira de Sá Emma J. van Bodegraven Henk Karst Oliver Harschnitz Marjolein A. M. Sneeboer Lill Eva Johansen Roland E. van Dijk Nicky Scheefhals Amber Berdenis van Berlekom Eduardo Ribes Martínez Sandra Kling Harold D. MacGillavry Leonard H. van den Berg René S. Kahn Elly M. Hol Lot D. de Witte R. Jeroen Pasterkamp |
| author_facet | Paul R. Ormel Renata Vieira de Sá Emma J. van Bodegraven Henk Karst Oliver Harschnitz Marjolein A. M. Sneeboer Lill Eva Johansen Roland E. van Dijk Nicky Scheefhals Amber Berdenis van Berlekom Eduardo Ribes Martínez Sandra Kling Harold D. MacGillavry Leonard H. van den Berg René S. Kahn Elly M. Hol Lot D. de Witte R. Jeroen Pasterkamp |
| author_sort | Paul R. Ormel |
| collection | DOAJ |
| description | Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment. |
| first_indexed | 2024-12-14T12:48:21Z |
| format | Article |
| id | doaj.art-0f43c1e80fff44ada197169a4b75a7dc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:48:21Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0f43c1e80fff44ada197169a4b75a7dc2022-12-21T23:00:43ZengNature PortfolioNature Communications2041-17232018-10-019111410.1038/s41467-018-06684-2Microglia innately develop within cerebral organoidsPaul R. Ormel0Renata Vieira de Sá1Emma J. van Bodegraven2Henk Karst3Oliver Harschnitz4Marjolein A. M. Sneeboer5Lill Eva Johansen6Roland E. van Dijk7Nicky Scheefhals8Amber Berdenis van Berlekom9Eduardo Ribes Martínez10Sandra Kling11Harold D. MacGillavry12Leonard H. van den Berg13René S. Kahn14Elly M. Hol15Lot D. de Witte16R. Jeroen Pasterkamp17Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityCell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityCell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8Department of Neurology, BCRM-UMCU, Utrecht UniversityDepartment of Psychiatry, BCRM-UMCU, Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht UniversityBrain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.https://doi.org/10.1038/s41467-018-06684-2 |
| spellingShingle | Paul R. Ormel Renata Vieira de Sá Emma J. van Bodegraven Henk Karst Oliver Harschnitz Marjolein A. M. Sneeboer Lill Eva Johansen Roland E. van Dijk Nicky Scheefhals Amber Berdenis van Berlekom Eduardo Ribes Martínez Sandra Kling Harold D. MacGillavry Leonard H. van den Berg René S. Kahn Elly M. Hol Lot D. de Witte R. Jeroen Pasterkamp Microglia innately develop within cerebral organoids Nature Communications |
| title | Microglia innately develop within cerebral organoids |
| title_full | Microglia innately develop within cerebral organoids |
| title_fullStr | Microglia innately develop within cerebral organoids |
| title_full_unstemmed | Microglia innately develop within cerebral organoids |
| title_short | Microglia innately develop within cerebral organoids |
| title_sort | microglia innately develop within cerebral organoids |
| url | https://doi.org/10.1038/s41467-018-06684-2 |
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