Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer Chemoprevention
Striking progress is being made in cancer treatment by using small molecule inhibitors of specific protein kinases that are products of genes recognized as drivers for a specific type of cancer. However, the cost of newly developed drugs is high, and these pharmaceuticals are neither affordable nor...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/5/1192 |
| _version_ | 1797614636063784960 |
|---|---|
| author | Henry J. Thompson Tymofiy Lutsiv |
| author_facet | Henry J. Thompson Tymofiy Lutsiv |
| author_sort | Henry J. Thompson |
| collection | DOAJ |
| description | Striking progress is being made in cancer treatment by using small molecule inhibitors of specific protein kinases that are products of genes recognized as drivers for a specific type of cancer. However, the cost of newly developed drugs is high, and these pharmaceuticals are neither affordable nor accessible in most parts of the world. Accordingly, this narrative review aims to probe how these recent successes in cancer treatment can be reverse-engineered into affordable and accessible approaches for the global community. This challenge is addressed through the lens of cancer chemoprevention, defined as using pharmacological agents of natural or synthetic origin to impede, arrest, or reverse carcinogenesis at any stage in the disease process. In this regard, prevention refers to reducing cancer-related deaths. Recognizing the clinical successes and limitations of protein kinase inhibitor treatment strategies, the disciplines of pharmacognosy and chemotaxonomy are juxtaposed with current efforts to exploit the cancer kinome to describe a conceptual framework for developing a natural product-based approach for precision oncology. |
| first_indexed | 2024-03-11T07:14:12Z |
| format | Article |
| id | doaj.art-0f4554d979b74e259c57671660865266 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T07:14:12Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0f4554d979b74e259c576716608652662023-11-17T08:20:54ZengMDPI AGNutrients2072-66432023-02-01155119210.3390/nu15051192Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer ChemopreventionHenry J. Thompson0Tymofiy Lutsiv1Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USACancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USAStriking progress is being made in cancer treatment by using small molecule inhibitors of specific protein kinases that are products of genes recognized as drivers for a specific type of cancer. However, the cost of newly developed drugs is high, and these pharmaceuticals are neither affordable nor accessible in most parts of the world. Accordingly, this narrative review aims to probe how these recent successes in cancer treatment can be reverse-engineered into affordable and accessible approaches for the global community. This challenge is addressed through the lens of cancer chemoprevention, defined as using pharmacological agents of natural or synthetic origin to impede, arrest, or reverse carcinogenesis at any stage in the disease process. In this regard, prevention refers to reducing cancer-related deaths. Recognizing the clinical successes and limitations of protein kinase inhibitor treatment strategies, the disciplines of pharmacognosy and chemotaxonomy are juxtaposed with current efforts to exploit the cancer kinome to describe a conceptual framework for developing a natural product-based approach for precision oncology.https://www.mdpi.com/2072-6643/15/5/1192cancer kinomechemopreventionnatural productssmall molecule inhibitorsprecision oncology |
| spellingShingle | Henry J. Thompson Tymofiy Lutsiv Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer Chemoprevention Nutrients cancer kinome chemoprevention natural products small molecule inhibitors precision oncology |
| title | Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer Chemoprevention |
| title_full | Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer Chemoprevention |
| title_fullStr | Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer Chemoprevention |
| title_full_unstemmed | Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer Chemoprevention |
| title_short | Natural Products in Precision Oncology: Plant-Based Small Molecule Inhibitors of Protein Kinases for Cancer Chemoprevention |
| title_sort | natural products in precision oncology plant based small molecule inhibitors of protein kinases for cancer chemoprevention |
| topic | cancer kinome chemoprevention natural products small molecule inhibitors precision oncology |
| url | https://www.mdpi.com/2072-6643/15/5/1192 |
| work_keys_str_mv | AT henryjthompson naturalproductsinprecisiononcologyplantbasedsmallmoleculeinhibitorsofproteinkinasesforcancerchemoprevention AT tymofiylutsiv naturalproductsinprecisiononcologyplantbasedsmallmoleculeinhibitorsofproteinkinasesforcancerchemoprevention |