C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37

C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37

To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with different TLR ligands. Protein staining followed...

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Bibliographic Details
Main Authors: Susanne Mommert, Lisa Doenni, Phillip Szudybill, Christoph Zoeller, Frerk Hinnerk Beyer, Thomas Werfel
Format: Article
Language:English
Published: Karger Publishers 2021-01-01
Series:Journal of Innate Immunity
Subjects:
c3a receptor
complement system
keratinocytes
pattern recognition receptors
Online Access:https://www.karger.com/Article/FullText/512547

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https://www.karger.com/Article/FullText/512547

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