Canine peripheral blood TCRαβ T cell atlas: Identification of diverse subsets including CD8A+ MAIT-like cells by combined single-cell transcriptome and V(D)J repertoire analysis

Canine peripheral blood TCRαβ T cell atlas: Identification of diverse subsets including CD8A+ MAIT-like cells by combined single-cell transcriptome and V(D)J repertoire analysis

The dog is valued as a companion animal and increasingly recognized as a model for human disorders. Given the importance of T cells in health and disease, comprehensive knowledge of canine T cells can contribute to our understanding of pathogenesis mechanisms and inform the development of new treatm...

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Bibliographic Details
Main Authors: Maria Eschke, Peter F. Moore, Haiyang Chang, Gottfried Alber, Stefan M. Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
dog
canine T cells
TCRαβ
single-cell RNA-sequencing
immune repertoire
peripheral blood
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1123366/full

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