Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus
ABSTRACTSince its genome details are publically available, the mosquito Aedes albopictus has become the central stage of attention for deciphering multiple biological and evolutionary aspects at the root of its success as an invasive species. Its genome of 1,967 Mb harbours an unusual high number of...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1657785 |
| _version_ | 1797385744362242048 |
|---|---|
| author | Vincent Houé Gaelle Gabiane Catherine Dauga Marie Suez Yoann Madec Laurence Mousson Michele Marconcini Pei-Shi Yen Xavier de Lamballerie Mariangela Bonizzoni Anna-Bella Failloux |
| author_facet | Vincent Houé Gaelle Gabiane Catherine Dauga Marie Suez Yoann Madec Laurence Mousson Michele Marconcini Pei-Shi Yen Xavier de Lamballerie Mariangela Bonizzoni Anna-Bella Failloux |
| author_sort | Vincent Houé |
| collection | DOAJ |
| description | ABSTRACTSince its genome details are publically available, the mosquito Aedes albopictus has become the central stage of attention for deciphering multiple biological and evolutionary aspects at the root of its success as an invasive species. Its genome of 1,967 Mb harbours an unusual high number of non-retroviral integrated RNA virus sequences (NIRVS). NIRVS are enriched in piRNA clusters and produce piRNAs, suggesting an antiviral effect. Here, we investigated the evolutionary history of NIRVS in geographically distant Ae. albopictus populations by comparing genetic variation as derived by neutral microsatellite loci and seven selected NIRVS. We found that the evolution of NIRVS was far to be neutral with variations both in their distribution and sequence polymorphism among Ae. albopictus populations. The Flaviviral elements AlbFlavi2 and AlbFlavi36 were more deeply investigated in their association with dissemination rates of dengue virus (DENV) and chikungunya virus (CHIKV) in Ae. albopictus at both population and individual levels. Our results show a complex association between NIRVS and DENV/CHIKV opening a new avenue for investigating the functional role of NIRVS as antiviral elements shaping vector competence of mosquitoes to arboviruses. |
| first_indexed | 2024-03-08T21:58:41Z |
| format | Article |
| id | doaj.art-0f471477ecb44f64a6d20ed34762e3b8 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T21:58:41Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-0f471477ecb44f64a6d20ed34762e3b82023-12-19T16:09:57ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811265127910.1080/22221751.2019.1657785Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictusVincent Houé0Gaelle Gabiane1Catherine Dauga2Marie Suez3Yoann Madec4Laurence Mousson5Michele Marconcini6Pei-Shi Yen7Xavier de Lamballerie8Mariangela Bonizzoni9Anna-Bella Failloux10Department of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, FranceDepartment of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, FranceInstitut Pasteur, Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), Paris, FranceInstitut de Biologie Paris-Seine, Paris, FranceDepartment of Infection and Epidemiology, Institut Pasteur, Epidemiology of Emerging Diseases, Paris, FranceDepartment of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, FranceDepartment of Biology and Biotechnology, University of Pavia, Pavia, ItalyDepartment of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, FranceAix Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health, EPV UMR_D 190 ‘Emergence des Pathologies Virales’, Marseille, FranceDepartment of Biology and Biotechnology, University of Pavia, Pavia, ItalyDepartment of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, FranceABSTRACTSince its genome details are publically available, the mosquito Aedes albopictus has become the central stage of attention for deciphering multiple biological and evolutionary aspects at the root of its success as an invasive species. Its genome of 1,967 Mb harbours an unusual high number of non-retroviral integrated RNA virus sequences (NIRVS). NIRVS are enriched in piRNA clusters and produce piRNAs, suggesting an antiviral effect. Here, we investigated the evolutionary history of NIRVS in geographically distant Ae. albopictus populations by comparing genetic variation as derived by neutral microsatellite loci and seven selected NIRVS. We found that the evolution of NIRVS was far to be neutral with variations both in their distribution and sequence polymorphism among Ae. albopictus populations. The Flaviviral elements AlbFlavi2 and AlbFlavi36 were more deeply investigated in their association with dissemination rates of dengue virus (DENV) and chikungunya virus (CHIKV) in Ae. albopictus at both population and individual levels. Our results show a complex association between NIRVS and DENV/CHIKV opening a new avenue for investigating the functional role of NIRVS as antiviral elements shaping vector competence of mosquitoes to arboviruses.https://www.tandfonline.com/doi/10.1080/22221751.2019.1657785Aedes albopictusarboviral diseasesgenetic structurevector competenceNIRVS |
| spellingShingle | Vincent Houé Gaelle Gabiane Catherine Dauga Marie Suez Yoann Madec Laurence Mousson Michele Marconcini Pei-Shi Yen Xavier de Lamballerie Mariangela Bonizzoni Anna-Bella Failloux Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus Emerging Microbes and Infections Aedes albopictus arboviral diseases genetic structure vector competence NIRVS |
| title | Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus |
| title_full | Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus |
| title_fullStr | Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus |
| title_full_unstemmed | Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus |
| title_short | Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus |
| title_sort | evolution and biological significance of flaviviral elements in the genome of the arboviral vector aedes albopictus |
| topic | Aedes albopictus arboviral diseases genetic structure vector competence NIRVS |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1657785 |
| work_keys_str_mv | AT vincenthoue evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT gaellegabiane evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT catherinedauga evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT mariesuez evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT yoannmadec evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT laurencemousson evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT michelemarconcini evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT peishiyen evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT xavierdelamballerie evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT mariangelabonizzoni evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus AT annabellafailloux evolutionandbiologicalsignificanceofflaviviralelementsinthegenomeofthearboviralvectoraedesalbopictus |