Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey
<h4>Background</h4> Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile disease caused by bites from ticks infected with the SFTS virus. In Korea, SFTS patients are observed nationwide, including Jeju Island, but there are currently no data regarding the national preva...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-03-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032665/?tool=EBI |
| _version_ | 1797860330794123264 |
|---|---|
| author | Choon-Mee Kim Mi Ah Han Na Ra Yun Mi-Seon Bang You Mi Lee Beomgi Lee Dong-Min Kim |
| author_facet | Choon-Mee Kim Mi Ah Han Na Ra Yun Mi-Seon Bang You Mi Lee Beomgi Lee Dong-Min Kim |
| author_sort | Choon-Mee Kim |
| collection | DOAJ |
| description | <h4>Background</h4> Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile disease caused by bites from ticks infected with the SFTS virus. In Korea, SFTS patients are observed nationwide, including Jeju Island, but there are currently no data regarding the national prevalence of SFTS, including that of residents of 16 cities and provinces. This study aimed to investigate the seroprevalence of SFTS in Korea. <h4>Methodology/Principal findings</h4> A total of 1500 participants were selected through random sampling from the 2014–2015 Korea National Health and Nutrition Examination Survey (KNHANES). An indirect immunofluorescence antibody assay (IFA) was performed to assess immunoglobulin (Ig) G and IgM antibody titers against SFTS virus. <h4>Results</h4> Of the 1500 participants, 55 (3.7%) tested positive for IgG and 1 (0.1%) tested positive for IgM, with antibody titer of ≥ 1:32. Approximately 3.9% and 2.5% of participants in urban and rural areas, respectively, had a positive titer of ≥ 1:32. There was a significant correlation between SFTS incidence per 100,000 population and seroprevalence using an IgG titer ≥ 1:64 as the cut-off value. <h4>Conclusion</h4> This is the first study to investigate national SFTS seroprevalence in all 16 cities and provinces representing Korea. Our study will also provide useful guidelines for the development of preventive measures against SFTS. Author summary Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile disease caused by a bite from a tick carrying the SFTS virus. This new infectious disease is observed mainly in Korea, China, and Japan. In Korea, SFTS incidence reported in Korea Disease Control and Prevention Agency is an average of 233 cases between 2016 and 2020, with 39 deaths and a fatality rate of 16.68%. SFTS patients are observed nationwide, including Jeju Island, but there are currently no data regarding the national prevalence of SFTS, including that of residents of 16 cities and provinces. In the present study, we aimed to investigate the seroprevalence of SFTS in Korea. A total of 1500 participants were selected through random sampling from the 2014–2015 Korea National Health and Nutrition Examination Survey. An indirect immunofluorescence antibody assay was performed to assess immunoglobulin (Ig) G and IgM antibody titers against SFTS virus. Of the 1500 participants, 55 (3.7%) tested positive for IgG and 1 (0.1%) tested positive for IgM, with antibody titer of ≥ 1:32. Approximately 3.9% and 2.5% of participants in urban and rural areas, respectively, had a positive titer of ≥ 1:32. There was a significant correlation between SFTS incidence per 100,000 population and seroprevalence using an IgG titer ≥ 1:64 as the cut-off value. This is the first study to investigate national SFTS seroprevalence across all 16 cities and provinces representing Korea; furthermore, our study will also provide useful guidelines for the development of preventive measures against SFTS. |
| first_indexed | 2024-04-09T21:44:07Z |
| format | Article |
| id | doaj.art-0f47148be20b494781f22d8e3d755bbd |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-09T21:44:07Z |
| publishDate | 2023-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-0f47148be20b494781f22d8e3d755bbd2023-03-25T05:31:38ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352023-03-01173Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination SurveyChoon-Mee KimMi Ah HanNa Ra YunMi-Seon BangYou Mi LeeBeomgi LeeDong-Min Kim<h4>Background</h4> Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile disease caused by bites from ticks infected with the SFTS virus. In Korea, SFTS patients are observed nationwide, including Jeju Island, but there are currently no data regarding the national prevalence of SFTS, including that of residents of 16 cities and provinces. This study aimed to investigate the seroprevalence of SFTS in Korea. <h4>Methodology/Principal findings</h4> A total of 1500 participants were selected through random sampling from the 2014–2015 Korea National Health and Nutrition Examination Survey (KNHANES). An indirect immunofluorescence antibody assay (IFA) was performed to assess immunoglobulin (Ig) G and IgM antibody titers against SFTS virus. <h4>Results</h4> Of the 1500 participants, 55 (3.7%) tested positive for IgG and 1 (0.1%) tested positive for IgM, with antibody titer of ≥ 1:32. Approximately 3.9% and 2.5% of participants in urban and rural areas, respectively, had a positive titer of ≥ 1:32. There was a significant correlation between SFTS incidence per 100,000 population and seroprevalence using an IgG titer ≥ 1:64 as the cut-off value. <h4>Conclusion</h4> This is the first study to investigate national SFTS seroprevalence in all 16 cities and provinces representing Korea. Our study will also provide useful guidelines for the development of preventive measures against SFTS. Author summary Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile disease caused by a bite from a tick carrying the SFTS virus. This new infectious disease is observed mainly in Korea, China, and Japan. In Korea, SFTS incidence reported in Korea Disease Control and Prevention Agency is an average of 233 cases between 2016 and 2020, with 39 deaths and a fatality rate of 16.68%. SFTS patients are observed nationwide, including Jeju Island, but there are currently no data regarding the national prevalence of SFTS, including that of residents of 16 cities and provinces. In the present study, we aimed to investigate the seroprevalence of SFTS in Korea. A total of 1500 participants were selected through random sampling from the 2014–2015 Korea National Health and Nutrition Examination Survey. An indirect immunofluorescence antibody assay was performed to assess immunoglobulin (Ig) G and IgM antibody titers against SFTS virus. Of the 1500 participants, 55 (3.7%) tested positive for IgG and 1 (0.1%) tested positive for IgM, with antibody titer of ≥ 1:32. Approximately 3.9% and 2.5% of participants in urban and rural areas, respectively, had a positive titer of ≥ 1:32. There was a significant correlation between SFTS incidence per 100,000 population and seroprevalence using an IgG titer ≥ 1:64 as the cut-off value. This is the first study to investigate national SFTS seroprevalence across all 16 cities and provinces representing Korea; furthermore, our study will also provide useful guidelines for the development of preventive measures against SFTS.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032665/?tool=EBI |
| spellingShingle | Choon-Mee Kim Mi Ah Han Na Ra Yun Mi-Seon Bang You Mi Lee Beomgi Lee Dong-Min Kim Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey PLoS Neglected Tropical Diseases |
| title | Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey |
| title_full | Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey |
| title_fullStr | Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey |
| title_full_unstemmed | Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey |
| title_short | Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey |
| title_sort | seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the korea national health nutrition examination survey |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032665/?tool=EBI |
| work_keys_str_mv | AT choonmeekim seroprevalenceofseverefeverwiththrombocytopeniasyndromeusingspecimensfromthekoreanationalhealthnutritionexaminationsurvey AT miahhan seroprevalenceofseverefeverwiththrombocytopeniasyndromeusingspecimensfromthekoreanationalhealthnutritionexaminationsurvey AT narayun seroprevalenceofseverefeverwiththrombocytopeniasyndromeusingspecimensfromthekoreanationalhealthnutritionexaminationsurvey AT miseonbang seroprevalenceofseverefeverwiththrombocytopeniasyndromeusingspecimensfromthekoreanationalhealthnutritionexaminationsurvey AT youmilee seroprevalenceofseverefeverwiththrombocytopeniasyndromeusingspecimensfromthekoreanationalhealthnutritionexaminationsurvey AT beomgilee seroprevalenceofseverefeverwiththrombocytopeniasyndromeusingspecimensfromthekoreanationalhealthnutritionexaminationsurvey AT dongminkim seroprevalenceofseverefeverwiththrombocytopeniasyndromeusingspecimensfromthekoreanationalhealthnutritionexaminationsurvey |