The role of fibroblast growth factor 18 in cancers: functions and signaling pathways
Fibroblast growth factor 18(FGF18) is a member of the fibroblast growth factor family (FGFs). FGF18 is a class of bioactive substances that can conduct biological signals, regulate cell growth, participate in tissue repair and other functions, and can promote the occurrence and development of differ...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1124520/full |
| _version_ | 1797830894076035072 |
|---|---|
| author | Yiming Zhou Sizheng Sun Tao Ling Yongzhen Chen Rongzhong Zhou Qiang You |
| author_facet | Yiming Zhou Sizheng Sun Tao Ling Yongzhen Chen Rongzhong Zhou Qiang You |
| author_sort | Yiming Zhou |
| collection | DOAJ |
| description | Fibroblast growth factor 18(FGF18) is a member of the fibroblast growth factor family (FGFs). FGF18 is a class of bioactive substances that can conduct biological signals, regulate cell growth, participate in tissue repair and other functions, and can promote the occurrence and development of different types of malignant tumors through various mechanisms. In this review, we focus on recent studies of FGF18 in the diagnosis, treatment, and prognosis of tumors in digestive, reproductive, urinary, respiratory, motor, and pediatric systems. These findings suggest that FGF18 may play an increasingly important role in the clinical evaluation of these malignancies. Overall, FGF18 can function as an important oncogene at different gene and protein levels, and can be used as a potential new therapeutic target and prognostic biomarker for these tumors. |
| first_indexed | 2024-04-09T13:43:39Z |
| format | Article |
| id | doaj.art-0f47c04a963248a0b39c6c4771914fdc |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T13:43:39Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0f47c04a963248a0b39c6c4771914fdc2023-05-09T05:44:02ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.11245201124520The role of fibroblast growth factor 18 in cancers: functions and signaling pathwaysYiming Zhou0Sizheng Sun1Tao Ling2Yongzhen Chen3Rongzhong Zhou4Qiang You5Department of Biotherapy, Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Biotherapy, Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaSecond Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, Zaoyang First People’s Hosipital, Zaoyang, ChinaDepartment of Biotherapy, Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaFibroblast growth factor 18(FGF18) is a member of the fibroblast growth factor family (FGFs). FGF18 is a class of bioactive substances that can conduct biological signals, regulate cell growth, participate in tissue repair and other functions, and can promote the occurrence and development of different types of malignant tumors through various mechanisms. In this review, we focus on recent studies of FGF18 in the diagnosis, treatment, and prognosis of tumors in digestive, reproductive, urinary, respiratory, motor, and pediatric systems. These findings suggest that FGF18 may play an increasingly important role in the clinical evaluation of these malignancies. Overall, FGF18 can function as an important oncogene at different gene and protein levels, and can be used as a potential new therapeutic target and prognostic biomarker for these tumors.https://www.frontiersin.org/articles/10.3389/fonc.2023.1124520/fullFGF18(FGFR) fibroblast growth factor receptorcancergene expressionpathway |
| spellingShingle | Yiming Zhou Sizheng Sun Tao Ling Yongzhen Chen Rongzhong Zhou Qiang You The role of fibroblast growth factor 18 in cancers: functions and signaling pathways Frontiers in Oncology FGF18 (FGFR) fibroblast growth factor receptor cancer gene expression pathway |
| title | The role of fibroblast growth factor 18 in cancers: functions and signaling pathways |
| title_full | The role of fibroblast growth factor 18 in cancers: functions and signaling pathways |
| title_fullStr | The role of fibroblast growth factor 18 in cancers: functions and signaling pathways |
| title_full_unstemmed | The role of fibroblast growth factor 18 in cancers: functions and signaling pathways |
| title_short | The role of fibroblast growth factor 18 in cancers: functions and signaling pathways |
| title_sort | role of fibroblast growth factor 18 in cancers functions and signaling pathways |
| topic | FGF18 (FGFR) fibroblast growth factor receptor cancer gene expression pathway |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1124520/full |
| work_keys_str_mv | AT yimingzhou theroleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT sizhengsun theroleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT taoling theroleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT yongzhenchen theroleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT rongzhongzhou theroleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT qiangyou theroleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT yimingzhou roleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT sizhengsun roleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT taoling roleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT yongzhenchen roleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT rongzhongzhou roleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways AT qiangyou roleoffibroblastgrowthfactor18incancersfunctionsandsignalingpathways |