Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane
The lipid droplet (LD) is a cytoplasmic organelle, but it also exists in the nucleus under some conditions or in some cell types. New studies have revealed that nuclear LDs do not occur by haphazard entry of cytoplasmic LDs. Instead, they are generated by specific mechanisms that are increasingly un...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-12-01
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| Series: | Contact |
| Online Access: | https://doi.org/10.1177/2515256419896965 |
| _version_ | 1811297676132614144 |
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| author | Kamil Sołtysik Yuki Ohsaki Toyoshi Fujimoto |
| author_facet | Kamil Sołtysik Yuki Ohsaki Toyoshi Fujimoto |
| author_sort | Kamil Sołtysik |
| collection | DOAJ |
| description | The lipid droplet (LD) is a cytoplasmic organelle, but it also exists in the nucleus under some conditions or in some cell types. New studies have revealed that nuclear LDs do not occur by haphazard entry of cytoplasmic LDs. Instead, they are generated by specific mechanisms that are increasingly understood. The inner nuclear membrane (INM) plays a critical role in nuclear LD formation in both mammalian hepatocytes and budding yeast, although in significantly different ways. Hepatocyte nuclear LDs derive from precursors of very low-density lipoprotein lacking apolipoprotein B-100, which form in the endoplasmic reticulum lumen and accumulate in intranuclear extensions of the perinuclear space called type I nucleoplasmic reticulum. In contrast, nuclear LDs in yeast are generated by triglyceride synthesized in the INM. Nuclear LDs in hepatocytes and budding yeast are both instrumental in the regulation of phospholipid synthesis; however, again they function in different ways. As the full functional importance is as yet unknown, the close relationship of nuclear LDs and the INM is an attractive target of research from both physiological and pathological perspectives. |
| first_indexed | 2024-04-13T06:07:38Z |
| format | Article |
| id | doaj.art-0f47d264a3f94ccbae43e1879a5bbad4 |
| institution | Directory Open Access Journal |
| issn | 2515-2564 |
| language | English |
| last_indexed | 2024-04-13T06:07:38Z |
| publishDate | 2019-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Contact |
| spelling | doaj.art-0f47d264a3f94ccbae43e1879a5bbad42022-12-22T02:59:10ZengSAGE PublishingContact2515-25642019-12-01210.1177/2515256419896965Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear MembraneKamil SołtysikYuki OhsakiToyoshi FujimotoThe lipid droplet (LD) is a cytoplasmic organelle, but it also exists in the nucleus under some conditions or in some cell types. New studies have revealed that nuclear LDs do not occur by haphazard entry of cytoplasmic LDs. Instead, they are generated by specific mechanisms that are increasingly understood. The inner nuclear membrane (INM) plays a critical role in nuclear LD formation in both mammalian hepatocytes and budding yeast, although in significantly different ways. Hepatocyte nuclear LDs derive from precursors of very low-density lipoprotein lacking apolipoprotein B-100, which form in the endoplasmic reticulum lumen and accumulate in intranuclear extensions of the perinuclear space called type I nucleoplasmic reticulum. In contrast, nuclear LDs in yeast are generated by triglyceride synthesized in the INM. Nuclear LDs in hepatocytes and budding yeast are both instrumental in the regulation of phospholipid synthesis; however, again they function in different ways. As the full functional importance is as yet unknown, the close relationship of nuclear LDs and the INM is an attractive target of research from both physiological and pathological perspectives.https://doi.org/10.1177/2515256419896965 |
| spellingShingle | Kamil Sołtysik Yuki Ohsaki Toyoshi Fujimoto Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane Contact |
| title | Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane |
| title_full | Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane |
| title_fullStr | Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane |
| title_full_unstemmed | Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane |
| title_short | Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane |
| title_sort | duo in a mystical realm nuclear lipid droplets and the inner nuclear membrane |
| url | https://doi.org/10.1177/2515256419896965 |
| work_keys_str_mv | AT kamilsołtysik duoinamysticalrealmnuclearlipiddropletsandtheinnernuclearmembrane AT yukiohsaki duoinamysticalrealmnuclearlipiddropletsandtheinnernuclearmembrane AT toyoshifujimoto duoinamysticalrealmnuclearlipiddropletsandtheinnernuclearmembrane |