Roles of the complement system in alcohol-induced liver disease
Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of the Liver
2020-10-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2020-0094.pdf |
| _version_ | 1819277064217296896 |
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| author | Yi Zhou Guandou Yuan Fudi Zhong Songqing He |
| author_facet | Yi Zhou Guandou Yuan Fudi Zhong Songqing He |
| author_sort | Yi Zhou |
| collection | DOAJ |
| description | Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a rational and novel avenue to postpone and even reverse the progression of disease and simultaneously promote the repair of liver injury. In this mini-review, we briefly summarize the recent research progress, especially focusing on the role of complement and oxidative stress-induced transfer RNA-derived fragments, which might help us to better understand the pathogenesis of ALD and provide aid in the development of novel therapeutic strategies for ALD. |
| first_indexed | 2024-12-23T23:50:10Z |
| format | Article |
| id | doaj.art-0f4878c97f894299a7806438f6a4ecf5 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-23T23:50:10Z |
| publishDate | 2020-10-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-0f4878c97f894299a7806438f6a4ecf52022-12-21T17:25:25ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2020-10-0126467768510.3350/cmh.2020.00941562Roles of the complement system in alcohol-induced liver diseaseYi Zhou0Guandou Yuan1Fudi ZhongSongqing He Division of Hepatobiliary Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, China Division of Hepatobiliary Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaAlcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a rational and novel avenue to postpone and even reverse the progression of disease and simultaneously promote the repair of liver injury. In this mini-review, we briefly summarize the recent research progress, especially focusing on the role of complement and oxidative stress-induced transfer RNA-derived fragments, which might help us to better understand the pathogenesis of ALD and provide aid in the development of novel therapeutic strategies for ALD.http://e-cmh.org/upload/pdf/cmh-2020-0094.pdfcomplement system proteinsliver diseasesalcoholicmolecular targeted therapy |
| spellingShingle | Yi Zhou Guandou Yuan Fudi Zhong Songqing He Roles of the complement system in alcohol-induced liver disease Clinical and Molecular Hepatology complement system proteins liver diseases alcoholic molecular targeted therapy |
| title | Roles of the complement system in alcohol-induced liver disease |
| title_full | Roles of the complement system in alcohol-induced liver disease |
| title_fullStr | Roles of the complement system in alcohol-induced liver disease |
| title_full_unstemmed | Roles of the complement system in alcohol-induced liver disease |
| title_short | Roles of the complement system in alcohol-induced liver disease |
| title_sort | roles of the complement system in alcohol induced liver disease |
| topic | complement system proteins liver diseases alcoholic molecular targeted therapy |
| url | http://e-cmh.org/upload/pdf/cmh-2020-0094.pdf |
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