Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma
Abstract Laryngeal cancer ranks as the second most prevalent upper airway malignancy, following Lung cancer. Although some progress has been made in managing laryngeal cancer, the 5-year survival rate is disappointing. The gradual increase in the incidence of second primary tumors (SPTs) plays a cru...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13027-023-00558-z |
| _version_ | 1797415954832949248 |
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| author | Meixuan Wan Xinxin Yang Lin He Hongxue Meng |
| author_facet | Meixuan Wan Xinxin Yang Lin He Hongxue Meng |
| author_sort | Meixuan Wan |
| collection | DOAJ |
| description | Abstract Laryngeal cancer ranks as the second most prevalent upper airway malignancy, following Lung cancer. Although some progress has been made in managing laryngeal cancer, the 5-year survival rate is disappointing. The gradual increase in the incidence of second primary tumors (SPTs) plays a crucial role in determining survival outcomes during long-term follow-up, and the esophagus was the most common site with a worse prognosis. In clinical practice, the treatment of esophageal second primary tumors (ESPT) in patients with laryngeal squamous cell carcinoma (LSCC) has always been challenging. For patients with synchronous tumors, several treatment modalities, such as radiotherapy, chemotherapy and potentially curative surgery are necessary but are typically poorly tolerated. Secondary cancer therapy options for metachronous patients are always constrained by index cancer treatment indications. Therefore, understanding the clonal origin of the second primary tumor may be an important issue in the treatment of patients. LSCC cells demonstrate genetic instability because of two distinct aetiologies (human papillomavirus (HPV)-negative and HPV-positive) disease. Various etiologies exhibit distinct oncogenic mechanisms, which subsequently impact the tissue microenvironment. The condition of the tissue microenvironment plays a crucial role in determining the destiny and clonal makeup of mutant cells during the initial stages of tumorigenesis. This review focuses on the genetic advances of LSCC, the current research status of SPT, and the influence of key carcinogenesis of HPV-positive and HPV-negative LSCC on clonal evolution of ESPT cells. The objective is to gain a comprehensive understanding of the molecular basis underlying the clonal origins of SPT, thereby offering novel perspectives for future investigations in this field. |
| first_indexed | 2024-03-09T05:56:54Z |
| format | Article |
| id | doaj.art-0f488f4633eb4df280ac9e0e9c47493a |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-03-09T05:56:54Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-0f488f4633eb4df280ac9e0e9c47493a2023-12-03T12:12:19ZengBMCInfectious Agents and Cancer1750-93782023-11-0118111210.1186/s13027-023-00558-zElucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinomaMeixuan Wan0Xinxin Yang1Lin He2Hongxue Meng3Department of Pathology, Harbin Medical University Cancer HospitalPrecision Medicine Center, Harbin Medical University Cancer HospitalDepartment of Stomatology, Heilongjiang Province HospitalDepartment of Pathology, Harbin Medical University Cancer HospitalAbstract Laryngeal cancer ranks as the second most prevalent upper airway malignancy, following Lung cancer. Although some progress has been made in managing laryngeal cancer, the 5-year survival rate is disappointing. The gradual increase in the incidence of second primary tumors (SPTs) plays a crucial role in determining survival outcomes during long-term follow-up, and the esophagus was the most common site with a worse prognosis. In clinical practice, the treatment of esophageal second primary tumors (ESPT) in patients with laryngeal squamous cell carcinoma (LSCC) has always been challenging. For patients with synchronous tumors, several treatment modalities, such as radiotherapy, chemotherapy and potentially curative surgery are necessary but are typically poorly tolerated. Secondary cancer therapy options for metachronous patients are always constrained by index cancer treatment indications. Therefore, understanding the clonal origin of the second primary tumor may be an important issue in the treatment of patients. LSCC cells demonstrate genetic instability because of two distinct aetiologies (human papillomavirus (HPV)-negative and HPV-positive) disease. Various etiologies exhibit distinct oncogenic mechanisms, which subsequently impact the tissue microenvironment. The condition of the tissue microenvironment plays a crucial role in determining the destiny and clonal makeup of mutant cells during the initial stages of tumorigenesis. This review focuses on the genetic advances of LSCC, the current research status of SPT, and the influence of key carcinogenesis of HPV-positive and HPV-negative LSCC on clonal evolution of ESPT cells. The objective is to gain a comprehensive understanding of the molecular basis underlying the clonal origins of SPT, thereby offering novel perspectives for future investigations in this field.https://doi.org/10.1186/s13027-023-00558-zLaryngeal squamous cell carcinomaEsophageal second primary tumorCloneField cancerizationEpigeneticsTumor microenvironment |
| spellingShingle | Meixuan Wan Xinxin Yang Lin He Hongxue Meng Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma Infectious Agents and Cancer Laryngeal squamous cell carcinoma Esophageal second primary tumor Clone Field cancerization Epigenetics Tumor microenvironment |
| title | Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma |
| title_full | Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma |
| title_fullStr | Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma |
| title_full_unstemmed | Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma |
| title_short | Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma |
| title_sort | elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma |
| topic | Laryngeal squamous cell carcinoma Esophageal second primary tumor Clone Field cancerization Epigenetics Tumor microenvironment |
| url | https://doi.org/10.1186/s13027-023-00558-z |
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