Advanced Materials and Devices for the Regulation and Study of NK Cells
Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/20/3/646 |
| _version_ | 1811342099056951296 |
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| author | Guillaume Le Saux Mark Schvartzman |
| author_facet | Guillaume Le Saux Mark Schvartzman |
| author_sort | Guillaume Le Saux |
| collection | DOAJ |
| description | Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental signals delivered through their diverse receptors. Recent advances in biomaterials and device engineering paved the way to numerous artificial microenvironments for cells, which produce synthetic signals identical or similar to those provided by the physiological environment. In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function. |
| first_indexed | 2024-04-13T19:05:27Z |
| format | Article |
| id | doaj.art-0f497bf17abe4da48905caf8bfca0ad6 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T19:05:27Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0f497bf17abe4da48905caf8bfca0ad62022-12-22T02:33:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-02-0120364610.3390/ijms20030646ijms20030646Advanced Materials and Devices for the Regulation and Study of NK CellsGuillaume Le Saux0Mark Schvartzman1Department of Materials Engineering, Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer Sheva 84105, IsraelDepartment of Materials Engineering, Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer Sheva 84105, IsraelNatural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental signals delivered through their diverse receptors. Recent advances in biomaterials and device engineering paved the way to numerous artificial microenvironments for cells, which produce synthetic signals identical or similar to those provided by the physiological environment. In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function.https://www.mdpi.com/1422-0067/20/3/646NK cellsimmune signalingbiomaterialsnanodevicesartificial immune synapse |
| spellingShingle | Guillaume Le Saux Mark Schvartzman Advanced Materials and Devices for the Regulation and Study of NK Cells International Journal of Molecular Sciences NK cells immune signaling biomaterials nanodevices artificial immune synapse |
| title | Advanced Materials and Devices for the Regulation and Study of NK Cells |
| title_full | Advanced Materials and Devices for the Regulation and Study of NK Cells |
| title_fullStr | Advanced Materials and Devices for the Regulation and Study of NK Cells |
| title_full_unstemmed | Advanced Materials and Devices for the Regulation and Study of NK Cells |
| title_short | Advanced Materials and Devices for the Regulation and Study of NK Cells |
| title_sort | advanced materials and devices for the regulation and study of nk cells |
| topic | NK cells immune signaling biomaterials nanodevices artificial immune synapse |
| url | https://www.mdpi.com/1422-0067/20/3/646 |
| work_keys_str_mv | AT guillaumelesaux advancedmaterialsanddevicesfortheregulationandstudyofnkcells AT markschvartzman advancedmaterialsanddevicesfortheregulationandstudyofnkcells |