1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia
Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathways in cancer cells. One-carbon (1-C) metabolism is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/3/190 |
| _version_ | 1797395141766414336 |
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| author | Kanwal Mahmood Ashkan Emadi |
| author_facet | Kanwal Mahmood Ashkan Emadi |
| author_sort | Kanwal Mahmood |
| collection | DOAJ |
| description | Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathways in cancer cells. One-carbon (1-C) metabolism is essential for numerous cancer cell functions, including protein and nucleic acid synthesis and maintaining cellular redox balance, and inhibition of the 1-C pathway has yielded several highly active drugs, such as methotrexate and 5-FU. Glutamine depletion has also emerged as a therapeutic approach for cancers that have demonstrated dependence on glutamine for survival. Recent studies have shown that in response to glutamine deprivation leukemia cells upregulate key enzymes in the serine biosynthesis pathway, suggesting that serine upregulation may be a targetable compensatory mechanism. These new findings may provide opportunities for novel cancer treatments. |
| first_indexed | 2024-03-09T00:30:08Z |
| format | Article |
| id | doaj.art-0f49afc8ba184d2eb7aec978fcbec918 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T00:30:08Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-0f49afc8ba184d2eb7aec978fcbec9182023-12-11T18:32:31ZengMDPI AGPharmaceuticals1424-82472021-02-0114319010.3390/ph140301901-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid LeukemiaKanwal Mahmood0Ashkan Emadi1Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USADepartment of Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USAMetabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathways in cancer cells. One-carbon (1-C) metabolism is essential for numerous cancer cell functions, including protein and nucleic acid synthesis and maintaining cellular redox balance, and inhibition of the 1-C pathway has yielded several highly active drugs, such as methotrexate and 5-FU. Glutamine depletion has also emerged as a therapeutic approach for cancers that have demonstrated dependence on glutamine for survival. Recent studies have shown that in response to glutamine deprivation leukemia cells upregulate key enzymes in the serine biosynthesis pathway, suggesting that serine upregulation may be a targetable compensatory mechanism. These new findings may provide opportunities for novel cancer treatments.https://www.mdpi.com/1424-8247/14/3/190amino acid metabolismcancer therapyleukemiaamino-acid-degrading enzymesamino acid restriction in cancer |
| spellingShingle | Kanwal Mahmood Ashkan Emadi 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia Pharmaceuticals amino acid metabolism cancer therapy leukemia amino-acid-degrading enzymes amino acid restriction in cancer |
| title | 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia |
| title_full | 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia |
| title_fullStr | 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia |
| title_full_unstemmed | 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia |
| title_short | 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia |
| title_sort | 1 c metabolism serine glycine folates in acute myeloid leukemia |
| topic | amino acid metabolism cancer therapy leukemia amino-acid-degrading enzymes amino acid restriction in cancer |
| url | https://www.mdpi.com/1424-8247/14/3/190 |
| work_keys_str_mv | AT kanwalmahmood 1cmetabolismserineglycinefolatesinacutemyeloidleukemia AT ashkanemadi 1cmetabolismserineglycinefolatesinacutemyeloidleukemia |