SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENT
Objective: Correction of the main treatment regimen for HIV/HCV co-infection, taking into account the degree of immunosuppression based on indices of CD4+ cells in 1 μl of blood and the severity of hepatic fibrosis tissue according to the elastometry of the liver Methods: A complex examination of...
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| Format: | Article |
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Avicenna Tajik State Medical University
2017-09-01
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| Series: | Паёми Сино |
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| Online Access: | https://doi.org/10.25005/2074-0581-2017-19-3-303-307 |
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| author | E.R. RAKHMANOV N.M. GULYAMOVA V.N. TSOY Т.М. SHARIPOV O. SAYFUDDINOV |
| author_facet | E.R. RAKHMANOV N.M. GULYAMOVA V.N. TSOY Т.М. SHARIPOV O. SAYFUDDINOV |
| author_sort | E.R. RAKHMANOV |
| collection | DOAJ |
| description | Objective: Correction of the main treatment regimen for HIV/HCV co-infection, taking into account the degree of immunosuppression based on indices of CD4+ cells in 1 μl of blood and the severity of hepatic fibrosis tissue according to the elastometry of the liver
Methods: A complex examination of 21 patients with HIV/HCV co-infection was carried out, according to anamnestic data who are the users of long-term injecting drugs. The diagnosis of HIV infection was confirmed by the positive result of the rapid test, ELISA, (enzyme-linked immunosorbent assay), immunoblotting. Hepatitis C virus is diagnosed by detection by ELISA of serum anti-HCV. To determine the degree of liver fibrosis, the method of elastometry on the FibroScan apparatus (France) was used on the basis of the Institute of Gastroenterology. The results were evaluated on a scale of the degree of fibrosis of liver METAVIR from F0 (healthy liver) to F4 (hepatic cirrhosis). The number of CD4+ lymphocytes in 1 μl of blood was determined by flow cytometry.
Results: With a targeted comprehensive examination of 21 patients with HIV/HCV co-infection, pronounced oscillations in the results of elastometry of the hepatic tissue (from F0 to F4), regardless of the number of CD4+ cells (24 to 809 cells/μl) were found.
Conclusion: The results obtained indicate that there is no direct correlation between the degree of immunosuppression in CD4+ indices and the process of formation of hepatic fibrosis in patients with co-infection with HIV/HCV, which is a significant additional diagnostic criterion in choosing the priority of therapy. |
| first_indexed | 2024-03-13T03:41:12Z |
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| id | doaj.art-0f4a4c5d36d548cbaec041ed4374c1b1 |
| institution | Directory Open Access Journal |
| issn | 2074-0581 2959-6327 |
| language | English |
| last_indexed | 2024-03-13T03:41:12Z |
| publishDate | 2017-09-01 |
| publisher | Avicenna Tajik State Medical University |
| record_format | Article |
| series | Паёми Сино |
| spelling | doaj.art-0f4a4c5d36d548cbaec041ed4374c1b12023-06-23T07:26:15ZengAvicenna Tajik State Medical UniversityПаёми Сино2074-05812959-63272017-09-0119330330710.25005/2074-0581-2017-19-3-303-307SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENTE.R. RAKHMANOV0N.M. GULYAMOVA1V.N. TSOY2Т.М. SHARIPOV3O. SAYFUDDINOV4Department of Infectious Diseases, Avicenna Tajik State Medical University, Dushanbe, TajikistanDepartment of Infectious Diseases, Avicenna Tajik State Medical University, Dushanbe, TajikistanDepartment of Infectious Diseases, Avicenna Tajik State Medical University, Dushanbe, TajikistanThe Local Center for AIDS Control and Prevention, Dushanbe, TajikistanInstitute of Gastroenterology, Dushanbe, TajikistanObjective: Correction of the main treatment regimen for HIV/HCV co-infection, taking into account the degree of immunosuppression based on indices of CD4+ cells in 1 μl of blood and the severity of hepatic fibrosis tissue according to the elastometry of the liver Methods: A complex examination of 21 patients with HIV/HCV co-infection was carried out, according to anamnestic data who are the users of long-term injecting drugs. The diagnosis of HIV infection was confirmed by the positive result of the rapid test, ELISA, (enzyme-linked immunosorbent assay), immunoblotting. Hepatitis C virus is diagnosed by detection by ELISA of serum anti-HCV. To determine the degree of liver fibrosis, the method of elastometry on the FibroScan apparatus (France) was used on the basis of the Institute of Gastroenterology. The results were evaluated on a scale of the degree of fibrosis of liver METAVIR from F0 (healthy liver) to F4 (hepatic cirrhosis). The number of CD4+ lymphocytes in 1 μl of blood was determined by flow cytometry. Results: With a targeted comprehensive examination of 21 patients with HIV/HCV co-infection, pronounced oscillations in the results of elastometry of the hepatic tissue (from F0 to F4), regardless of the number of CD4+ cells (24 to 809 cells/μl) were found. Conclusion: The results obtained indicate that there is no direct correlation between the degree of immunosuppression in CD4+ indices and the process of formation of hepatic fibrosis in patients with co-infection with HIV/HCV, which is a significant additional diagnostic criterion in choosing the priority of therapy.https://doi.org/10.25005/2074-0581-2017-19-3-303-307elastometryimmunosuppressionco-infectionhivhcv. |
| spellingShingle | E.R. RAKHMANOV N.M. GULYAMOVA V.N. TSOY Т.М. SHARIPOV O. SAYFUDDINOV SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENT Паёми Сино elastometry immunosuppression co-infection hiv hcv. |
| title | SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENT |
| title_full | SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENT |
| title_fullStr | SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENT |
| title_full_unstemmed | SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENT |
| title_short | SIGNIFICANCE OF IMMUNOSUPPRESSION AND ELASTOMETRY INDICES OF LIVER IN THE TACTICS OF HIV/HCV CO-INFECTION TREATMENT |
| title_sort | significance of immunosuppression and elastometry indices of liver in the tactics of hiv hcv co infection treatment |
| topic | elastometry immunosuppression co-infection hiv hcv. |
| url | https://doi.org/10.25005/2074-0581-2017-19-3-303-307 |
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