The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
Cardiometabolic diseases (CMDs), including cardiovascular disease (CVD), metabolic syndrome (MetS), and type 2 diabetes (T2D), are associated with increased morbidity and mortality. The growing prevalence of CVD is mostly attributed to the aging population and common occurrence of risk factors, such...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6382 |
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| author | Iwona Świątkiewicz Marcin Wróblewski Jarosław Nuszkiewicz Paweł Sutkowy Joanna Wróblewska Alina Woźniak |
| author_facet | Iwona Świątkiewicz Marcin Wróblewski Jarosław Nuszkiewicz Paweł Sutkowy Joanna Wróblewska Alina Woźniak |
| author_sort | Iwona Świątkiewicz |
| collection | DOAJ |
| description | Cardiometabolic diseases (CMDs), including cardiovascular disease (CVD), metabolic syndrome (MetS), and type 2 diabetes (T2D), are associated with increased morbidity and mortality. The growing prevalence of CVD is mostly attributed to the aging population and common occurrence of risk factors, such as high systolic blood pressure, elevated plasma glucose, and increased body mass index, which led to a global epidemic of obesity, MetS, and T2D. Oxidant–antioxidant balance disorders largely contribute to the pathogenesis and outcomes of CMDs, such as systemic essential hypertension, coronary artery disease, stroke, and MetS. Enhanced and disturbed generation of reactive oxygen species in excess adipose tissue during obesity may lead to increased oxidative stress. Understanding the interplay between adiposity, oxidative stress, and cardiometabolic risks can have translational impacts, leading to the identification of novel effective strategies for reducing the CMDs burden. The present review article is based on extant results from basic and clinical studies and specifically addresses the various aspects associated with oxidant–antioxidant balance disorders in the course of CMDs in subjects with excess adipose tissue accumulation. We aim at giving a comprehensive overview of existing knowledge, knowledge gaps, and future perspectives for further basic and clinical research. We provide insights into both the mechanisms and clinical implications of effects related to the interplay between adiposity and oxidative stress for treating and preventing CMDs. Future basic research and clinical trials are needed to further examine the mechanisms of adiposity-enhanced oxidative stress in CMDs and the efficacy of antioxidant therapies for reducing risk and improving outcome of patients with CMDs. |
| first_indexed | 2024-03-11T05:34:32Z |
| format | Article |
| id | doaj.art-0f4bc71b95c54ec682ff5f0c23930f91 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:34:32Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0f4bc71b95c54ec682ff5f0c23930f912023-11-17T16:50:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247638210.3390/ijms24076382The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic DiseasesIwona Świątkiewicz0Marcin Wróblewski1Jarosław Nuszkiewicz2Paweł Sutkowy3Joanna Wróblewska4Alina Woźniak5Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, PolandCardiometabolic diseases (CMDs), including cardiovascular disease (CVD), metabolic syndrome (MetS), and type 2 diabetes (T2D), are associated with increased morbidity and mortality. The growing prevalence of CVD is mostly attributed to the aging population and common occurrence of risk factors, such as high systolic blood pressure, elevated plasma glucose, and increased body mass index, which led to a global epidemic of obesity, MetS, and T2D. Oxidant–antioxidant balance disorders largely contribute to the pathogenesis and outcomes of CMDs, such as systemic essential hypertension, coronary artery disease, stroke, and MetS. Enhanced and disturbed generation of reactive oxygen species in excess adipose tissue during obesity may lead to increased oxidative stress. Understanding the interplay between adiposity, oxidative stress, and cardiometabolic risks can have translational impacts, leading to the identification of novel effective strategies for reducing the CMDs burden. The present review article is based on extant results from basic and clinical studies and specifically addresses the various aspects associated with oxidant–antioxidant balance disorders in the course of CMDs in subjects with excess adipose tissue accumulation. We aim at giving a comprehensive overview of existing knowledge, knowledge gaps, and future perspectives for further basic and clinical research. We provide insights into both the mechanisms and clinical implications of effects related to the interplay between adiposity and oxidative stress for treating and preventing CMDs. Future basic research and clinical trials are needed to further examine the mechanisms of adiposity-enhanced oxidative stress in CMDs and the efficacy of antioxidant therapies for reducing risk and improving outcome of patients with CMDs.https://www.mdpi.com/1422-0067/24/7/6382oxidative stressobesitycardiovascular diseasecardiometabolic diseasescoronary artery diseasemetabolic syndrome |
| spellingShingle | Iwona Świątkiewicz Marcin Wróblewski Jarosław Nuszkiewicz Paweł Sutkowy Joanna Wróblewska Alina Woźniak The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases International Journal of Molecular Sciences oxidative stress obesity cardiovascular disease cardiometabolic diseases coronary artery disease metabolic syndrome |
| title | The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases |
| title_full | The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases |
| title_fullStr | The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases |
| title_full_unstemmed | The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases |
| title_short | The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases |
| title_sort | role of oxidative stress enhanced by adiposity in cardiometabolic diseases |
| topic | oxidative stress obesity cardiovascular disease cardiometabolic diseases coronary artery disease metabolic syndrome |
| url | https://www.mdpi.com/1422-0067/24/7/6382 |
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