Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation
The efficiency of using the culture techniques of research for monitoring the patient’s response to the treatment by tyrosine kinase inhibitors of the first and second generation is shown. Thus, the functional activity of bone marrow cells in patients having the optimal treatment response to inhibit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Oles Honchar Dnipropetrovsk National University
2014-07-01
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| Series: | Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Medicina |
| Subjects: | |
| Online Access: | http://medicine.dp.ua/index.php/med/article/view/226 |
| _version_ | 1811338384445014016 |
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| author | I. O. Zhaleyko D. I. Bilko I. S. Dyagil N. M. Bilko |
| author_facet | I. O. Zhaleyko D. I. Bilko I. S. Dyagil N. M. Bilko |
| author_sort | I. O. Zhaleyko |
| collection | DOAJ |
| description | The efficiency of using the culture techniques of research for monitoring the patient’s response to the treatment by tyrosine kinase inhibitors of the first and second generation is shown. Thus, the functional activity of bone marrow cells in patients having the optimal treatment response to inhibitors of tyrosine kinases was significantly lower compared with patients with the acquired resistance to the drug, and patients who had CML diagnosed for first time. Furthermore, for patients with the optimal response to the nilotinib therapy, numbers of colonies in semi-solid agar in vitro was lower, than in patients with the optimal response to imatinib. When the leukaemic cell clone becomes resistant to tyrosine kinase inhibitors, the prevalence of early cells of granulocyte-macrophage hematopoietic stem cells is observed in CFU culture which can be an important prognostic factor for choosing the appropriate treatment strategy. |
| first_indexed | 2024-04-13T18:09:55Z |
| format | Article |
| id | doaj.art-0f4d86102d564d8dbe3583b30844a8bc |
| institution | Directory Open Access Journal |
| issn | 2310-4155 2312-7295 |
| language | English |
| last_indexed | 2024-04-13T18:09:55Z |
| publishDate | 2014-07-01 |
| publisher | Oles Honchar Dnipropetrovsk National University |
| record_format | Article |
| series | Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Medicina |
| spelling | doaj.art-0f4d86102d564d8dbe3583b30844a8bc2022-12-22T02:35:56ZengOles Honchar Dnipropetrovsk National UniversityVìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Medicina2310-41552312-72952014-07-015210410910.15421/021420194Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generationI. O. Zhaleyko0D. I. Bilko1I. S. Dyagil2N. M. Bilko3Centre for Molecular and Cell Research of the National University of Kyiv-Mohyla AcademyCentre for Molecular and Cell Research of the National University of Kyiv-Mohyla AcademyScientific Centre of the Radiation Medicine NAMS of UkraineCentre for Molecular and Cell Research of the National University of Kyiv-Mohyla AcademyThe efficiency of using the culture techniques of research for monitoring the patient’s response to the treatment by tyrosine kinase inhibitors of the first and second generation is shown. Thus, the functional activity of bone marrow cells in patients having the optimal treatment response to inhibitors of tyrosine kinases was significantly lower compared with patients with the acquired resistance to the drug, and patients who had CML diagnosed for first time. Furthermore, for patients with the optimal response to the nilotinib therapy, numbers of colonies in semi-solid agar in vitro was lower, than in patients with the optimal response to imatinib. When the leukaemic cell clone becomes resistant to tyrosine kinase inhibitors, the prevalence of early cells of granulocyte-macrophage hematopoietic stem cells is observed in CFU culture which can be an important prognostic factor for choosing the appropriate treatment strategy.http://medicine.dp.ua/index.php/med/article/view/226chronic myeloid leukemiacell culture in vitrotyrosine kinase inhibitors |
| spellingShingle | I. O. Zhaleyko D. I. Bilko I. S. Dyagil N. M. Bilko Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Medicina chronic myeloid leukemia cell culture in vitro tyrosine kinase inhibitors |
| title | Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation |
| title_full | Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation |
| title_fullStr | Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation |
| title_full_unstemmed | Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation |
| title_short | Comparative evaluation of bone marrow cells morpho-functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation |
| title_sort | comparative evaluation of bone marrow cells morpho functional activity in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors of the first and second generation |
| topic | chronic myeloid leukemia cell culture in vitro tyrosine kinase inhibitors |
| url | http://medicine.dp.ua/index.php/med/article/view/226 |
| work_keys_str_mv | AT iozhaleyko comparativeevaluationofbonemarrowcellsmorphofunctionalactivityinchronicmyeloidleukemiapatientstreatedwithtyrosinekinaseinhibitorsofthefirstandsecondgeneration AT dibilko comparativeevaluationofbonemarrowcellsmorphofunctionalactivityinchronicmyeloidleukemiapatientstreatedwithtyrosinekinaseinhibitorsofthefirstandsecondgeneration AT isdyagil comparativeevaluationofbonemarrowcellsmorphofunctionalactivityinchronicmyeloidleukemiapatientstreatedwithtyrosinekinaseinhibitorsofthefirstandsecondgeneration AT nmbilko comparativeevaluationofbonemarrowcellsmorphofunctionalactivityinchronicmyeloidleukemiapatientstreatedwithtyrosinekinaseinhibitorsofthefirstandsecondgeneration |