Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients
Background: FAM83H is important in teeth development; however, an increasing number of reports have indicated a role for it in human cancers. FAM83H is involved in cancer progression in association with various oncogenic molecules, including SCRIB. In the analysis of the public database, there was a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/7/1579 |
| _version_ | 1827624118186409984 |
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| author | Tae Young Jeong Hae In Lee Min Su Park Min Young Seo Kyu Yun Jang |
| author_facet | Tae Young Jeong Hae In Lee Min Su Park Min Young Seo Kyu Yun Jang |
| author_sort | Tae Young Jeong |
| collection | DOAJ |
| description | Background: FAM83H is important in teeth development; however, an increasing number of reports have indicated a role for it in human cancers. FAM83H is involved in cancer progression in association with various oncogenic molecules, including SCRIB. In the analysis of the public database, there was a significant association between FAM83H and SCRIB in colorectal carcinomas. However, studies evaluating the association of FAM83H and SCRIB in colorectal carcinoma have been limited. Methods: The clinicopathological significance of the immunohistochemical expression of FAM83H and SCRIB was evaluated in 222 colorectal carcinomas. Results: The expressions of FAM83H and SCRIB were significantly associated in colorectal carcinoma tissue. In univariate analysis, the nuclear expressions of FAM83H and SCRIB and the cytoplasmic expression of SCRIB were significantly associated with shorter survival of colorectal carcinomas. The nuclear expressions of FAM83H and SCRIB and the cytoplasmic expression of SCRIB were independent indicators of shorter cancer-specific survival in multivariate analysis. A co-expression pattern of nuclear FAM83H and cytoplasmic SCRIB predicted shorter cancer-specific survival (<i>p</i> < 0.001) and relapse-free survival (<i>p</i> = 0.032) in multivariate analysis. Conclusions: This study suggests that FAM83H and SCRIB might be used as prognostic markers of colorectal carcinomas and as potential therapeutic targets for colorectal carcinomas. |
| first_indexed | 2024-03-09T12:01:20Z |
| format | Article |
| id | doaj.art-0f4fbfc51a6c459d99dee90c7de7273a |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T12:01:20Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-0f4fbfc51a6c459d99dee90c7de7273a2023-11-30T23:02:54ZengMDPI AGDiagnostics2075-44182022-06-01127157910.3390/diagnostics12071579Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma PatientsTae Young Jeong0Hae In Lee1Min Su Park2Min Young Seo3Kyu Yun Jang4Department of Medicine, Jeonbuk National University Medical School, Jeonju 54896, KoreaDepartment of Medicine, Jeonbuk National University Medical School, Jeonju 54896, KoreaDepartment of Medicine, Jeonbuk National University Medical School, Jeonju 54896, KoreaDepartment of Medicine, Jeonbuk National University Medical School, Jeonju 54896, KoreaDepartment of Pathology, Jeonbuk National University Medical School, Jeonju 54896, KoreaBackground: FAM83H is important in teeth development; however, an increasing number of reports have indicated a role for it in human cancers. FAM83H is involved in cancer progression in association with various oncogenic molecules, including SCRIB. In the analysis of the public database, there was a significant association between FAM83H and SCRIB in colorectal carcinomas. However, studies evaluating the association of FAM83H and SCRIB in colorectal carcinoma have been limited. Methods: The clinicopathological significance of the immunohistochemical expression of FAM83H and SCRIB was evaluated in 222 colorectal carcinomas. Results: The expressions of FAM83H and SCRIB were significantly associated in colorectal carcinoma tissue. In univariate analysis, the nuclear expressions of FAM83H and SCRIB and the cytoplasmic expression of SCRIB were significantly associated with shorter survival of colorectal carcinomas. The nuclear expressions of FAM83H and SCRIB and the cytoplasmic expression of SCRIB were independent indicators of shorter cancer-specific survival in multivariate analysis. A co-expression pattern of nuclear FAM83H and cytoplasmic SCRIB predicted shorter cancer-specific survival (<i>p</i> < 0.001) and relapse-free survival (<i>p</i> = 0.032) in multivariate analysis. Conclusions: This study suggests that FAM83H and SCRIB might be used as prognostic markers of colorectal carcinomas and as potential therapeutic targets for colorectal carcinomas.https://www.mdpi.com/2075-4418/12/7/1579colorectumcarcinomaimmunohistochemistryFAM83HSCRIBprognosis |
| spellingShingle | Tae Young Jeong Hae In Lee Min Su Park Min Young Seo Kyu Yun Jang Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients Diagnostics colorectum carcinoma immunohistochemistry FAM83H SCRIB prognosis |
| title | Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients |
| title_full | Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients |
| title_fullStr | Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients |
| title_full_unstemmed | Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients |
| title_short | Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients |
| title_sort | individual and co expression patterns of fam83h and scrib at diagnosis are associated with the survival of colorectal carcinoma patients |
| topic | colorectum carcinoma immunohistochemistry FAM83H SCRIB prognosis |
| url | https://www.mdpi.com/2075-4418/12/7/1579 |
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