Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-Up
Although the lungs are the primary organ involved, increasing evidence supports the neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigates the potential relationship between coronavirus disease (COVID-19)-related deterioration of brain struct...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/4/781 |
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| author | Shizhen Chen Yina Lan Haidong Li Liming Xia Chaohui Ye Xin Lou Xin Zhou |
| author_facet | Shizhen Chen Yina Lan Haidong Li Liming Xia Chaohui Ye Xin Lou Xin Zhou |
| author_sort | Shizhen Chen |
| collection | DOAJ |
| description | Although the lungs are the primary organ involved, increasing evidence supports the neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigates the potential relationship between coronavirus disease (COVID-19)-related deterioration of brain structure and the degree of damage to lung function. Nine COVID-19 patients were recruited in critical condition from Jin Yin-tan Hospital (Wuhan, China) who had been discharged between 4 February and 27 February 2020. The demographic, clinical, treatment, and laboratory data were extracted from the electronic medical records. All patients underwent chest CT imaging, <sup>129</sup>Xe gas lung MRI, and <sup>1</sup>H brain MRI. Four of the patients were followed up for 8 months. After nearly 12 months of recovery, we found no significant difference in lung ventilation defect percentage (VDP) between the COVID-19 group and the healthy group (3.8 ± 2.1% versus 3.7 ± 2.2%) using <sup>129</sup>Xe MRI, and several lung-function-related parameters—such as gas–blood exchange time (T)—showed improvement (42.2 ms versus 32.5 ms). Combined with <sup>1</sup>H brain MRI, we found that the change in gray matter volume (GMV) was strongly related to the degree of pulmonary function recovery—the greater the increase in GMV, the higher degree of pulmonary function damage. |
| first_indexed | 2024-03-09T11:07:47Z |
| format | Article |
| id | doaj.art-0f50061605814b75b98d7ae0ae481fb8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:07:47Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0f50061605814b75b98d7ae0ae481fb82023-12-01T00:53:14ZengMDPI AGBiomedicines2227-90592022-03-0110478110.3390/biomedicines10040781Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-UpShizhen Chen0Yina Lan1Haidong Li2Liming Xia3Chaohui Ye4Xin Lou5Xin Zhou6State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, ChinaDepartment of Radiology, Chinese PLA General Hospital, Beijing 100853, ChinaState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, ChinaDepartment of Radiology, Chinese PLA General Hospital, Beijing 100853, ChinaState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, ChinaAlthough the lungs are the primary organ involved, increasing evidence supports the neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigates the potential relationship between coronavirus disease (COVID-19)-related deterioration of brain structure and the degree of damage to lung function. Nine COVID-19 patients were recruited in critical condition from Jin Yin-tan Hospital (Wuhan, China) who had been discharged between 4 February and 27 February 2020. The demographic, clinical, treatment, and laboratory data were extracted from the electronic medical records. All patients underwent chest CT imaging, <sup>129</sup>Xe gas lung MRI, and <sup>1</sup>H brain MRI. Four of the patients were followed up for 8 months. After nearly 12 months of recovery, we found no significant difference in lung ventilation defect percentage (VDP) between the COVID-19 group and the healthy group (3.8 ± 2.1% versus 3.7 ± 2.2%) using <sup>129</sup>Xe MRI, and several lung-function-related parameters—such as gas–blood exchange time (T)—showed improvement (42.2 ms versus 32.5 ms). Combined with <sup>1</sup>H brain MRI, we found that the change in gray matter volume (GMV) was strongly related to the degree of pulmonary function recovery—the greater the increase in GMV, the higher degree of pulmonary function damage.https://www.mdpi.com/2227-9059/10/4/781<sup>129</sup>Xe gas MRIgas–blood exchange lung functionCOVID-19 pneumonialong-term follow-upmultiorgan involvement |
| spellingShingle | Shizhen Chen Yina Lan Haidong Li Liming Xia Chaohui Ye Xin Lou Xin Zhou Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-Up Biomedicines <sup>129</sup>Xe gas MRI gas–blood exchange lung function COVID-19 pneumonia long-term follow-up multiorgan involvement |
| title | Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-Up |
| title_full | Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-Up |
| title_fullStr | Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-Up |
| title_full_unstemmed | Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-Up |
| title_short | Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized <sup>129</sup>Xe-MRI-based 8-Month Follow-Up |
| title_sort | relationship between lung and brain injury in covid 19 patients a hyperpolarized sup 129 sup xe mri based 8 month follow up |
| topic | <sup>129</sup>Xe gas MRI gas–blood exchange lung function COVID-19 pneumonia long-term follow-up multiorgan involvement |
| url | https://www.mdpi.com/2227-9059/10/4/781 |
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