Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical center
Background/Purpose: High-dose-rate (HDR) electronic brachytherapy (EBT) has been shown to be effective for non-melanoma skin cancer (NMSC) in Caucasian patients. However, its efficacy remains unknown in Asian patients. To analyze the clinical outcome of HDR EBT for NMSC in a Taiwanese medical center...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664622001814 |
| _version_ | 1798019537699864576 |
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| author | Tsz-Yi Tang Jen-Yang Tang Stephen Chu-Sung Hu Khale Chiao-Li Ke Shih-Tsung Cheng |
| author_facet | Tsz-Yi Tang Jen-Yang Tang Stephen Chu-Sung Hu Khale Chiao-Li Ke Shih-Tsung Cheng |
| author_sort | Tsz-Yi Tang |
| collection | DOAJ |
| description | Background/Purpose: High-dose-rate (HDR) electronic brachytherapy (EBT) has been shown to be effective for non-melanoma skin cancer (NMSC) in Caucasian patients. However, its efficacy remains unknown in Asian patients. To analyze the clinical outcome of HDR EBT for NMSC in a Taiwanese medical center. Methods: Medical records over a 5-year period between January 2015 to December 2019 were retrospectively analyzed. Results: Forty-seven patients with 54 NMSC including 42 basal cell carcinomas (BCCs) and 12 squamous cell carcinomas (SCCs) were treated with HDR EBT. The average age was 73.8 years. The mean radiation dose was 45.3 Gy (40–80 Gy). Mean follow-up duration was 33.1 months. Adequate local control was achieved in 50 lesions (92.6%). Grade 1 acute skin toxicity was noted in 63.0% of lesions, while no tumors had Grade 4 acute toxicity. No ulceration was observed six months after completion of treatment. At the last follow-up visit, all lesions were rated to have “fair” to “excellent” cosmetic outcomes. Conclusion: HDR EBT provides adequate clinical outcomes and cosmetic results for NMSC in Asian patients. Further investigation of the dosage guidelines is needed for Asian patients with NMSC. |
| first_indexed | 2024-04-11T16:42:17Z |
| format | Article |
| id | doaj.art-0f510e8f4f044eb799e2b3a34c84f904 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-11T16:42:17Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-0f510e8f4f044eb799e2b3a34c84f9042022-12-22T04:13:38ZengElsevierJournal of the Formosan Medical Association0929-66462022-11-011211123172323Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical centerTsz-Yi Tang0Jen-Yang Tang1Stephen Chu-Sung Hu2Khale Chiao-Li Ke3Shih-Tsung Cheng4Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Psychiatry, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Corresponding author.Background/Purpose: High-dose-rate (HDR) electronic brachytherapy (EBT) has been shown to be effective for non-melanoma skin cancer (NMSC) in Caucasian patients. However, its efficacy remains unknown in Asian patients. To analyze the clinical outcome of HDR EBT for NMSC in a Taiwanese medical center. Methods: Medical records over a 5-year period between January 2015 to December 2019 were retrospectively analyzed. Results: Forty-seven patients with 54 NMSC including 42 basal cell carcinomas (BCCs) and 12 squamous cell carcinomas (SCCs) were treated with HDR EBT. The average age was 73.8 years. The mean radiation dose was 45.3 Gy (40–80 Gy). Mean follow-up duration was 33.1 months. Adequate local control was achieved in 50 lesions (92.6%). Grade 1 acute skin toxicity was noted in 63.0% of lesions, while no tumors had Grade 4 acute toxicity. No ulceration was observed six months after completion of treatment. At the last follow-up visit, all lesions were rated to have “fair” to “excellent” cosmetic outcomes. Conclusion: HDR EBT provides adequate clinical outcomes and cosmetic results for NMSC in Asian patients. Further investigation of the dosage guidelines is needed for Asian patients with NMSC.http://www.sciencedirect.com/science/article/pii/S0929664622001814Electronic brachytherapyNon-melanoma skin cancerBasal cell carcinomaSquamous cell carcinomaAsian |
| spellingShingle | Tsz-Yi Tang Jen-Yang Tang Stephen Chu-Sung Hu Khale Chiao-Li Ke Shih-Tsung Cheng Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical center Journal of the Formosan Medical Association Electronic brachytherapy Non-melanoma skin cancer Basal cell carcinoma Squamous cell carcinoma Asian |
| title | Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical center |
| title_full | Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical center |
| title_fullStr | Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical center |
| title_full_unstemmed | Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical center |
| title_short | Electronic brachytherapy for non-melanoma skin cancer in Asians: Experience from a Taiwan medical center |
| title_sort | electronic brachytherapy for non melanoma skin cancer in asians experience from a taiwan medical center |
| topic | Electronic brachytherapy Non-melanoma skin cancer Basal cell carcinoma Squamous cell carcinoma Asian |
| url | http://www.sciencedirect.com/science/article/pii/S0929664622001814 |
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