Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma
Background/purpose: Oral squamous cell carcinoma (OSCC) is highly prevalent worldwide. Lysyl oxidase (LOX) is an important enzyme that modulates the extracellular matrix. The LOX superfamily contains LOX and LOX-like (LOXL) enzymes. The aim of the present study was to determine the expressions of LO...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2011-12-01
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| Series: | Journal of Dental Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S199179021100078X |
| _version_ | 1818152178657787904 |
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| author | Tzong-Ming Shieh Shun-Yao Ko Shu-Shin Chang Kuo-Wei Chang Yin-Hua Shih Chung-Ji Liu |
| author_facet | Tzong-Ming Shieh Shun-Yao Ko Shu-Shin Chang Kuo-Wei Chang Yin-Hua Shih Chung-Ji Liu |
| author_sort | Tzong-Ming Shieh |
| collection | DOAJ |
| description | Background/purpose: Oral squamous cell carcinoma (OSCC) is highly prevalent worldwide. Lysyl oxidase (LOX) is an important enzyme that modulates the extracellular matrix. The LOX superfamily contains LOX and LOX-like (LOXL) enzymes. The aim of the present study was to determine the expressions of LOXL genes in OSCC.
Materials and methods: RT-PCR was performed to detect messenger (m)RNA expression of the LOXL genes, LOX-L1, -L3, and -L4, in paired OSCC and non-cancerous matched tissues (NCMTs).
Results: Increased mRNA expressions of LOX-L1 and LOX-L3 in OSCC relative to NCMTs were identified in 41% and 65% of OSCC samples, respectively. The normalized mRNA expression of LOXL-3 was 1.11 ± 0.15 in OSCC, which was significantly higher than 0.68 ± 0.12 in NCMTs (P = 0.004). The increased expression of LOX-L3 was associated with worse survival of OSCC patients (P = 0.028).
Conclusion: The results indicated the frequent increase in LOX-L3 mRNA expression in OSCC, and the value of LOX-L3 mRNA expression might have clinical uses in monitoring OSCC. |
| first_indexed | 2024-12-11T13:50:36Z |
| format | Article |
| id | doaj.art-0f512d0786624de0a59dd043c7cd41f4 |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-12-11T13:50:36Z |
| publishDate | 2011-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-0f512d0786624de0a59dd043c7cd41f42022-12-22T01:04:17ZengElsevierJournal of Dental Sciences1991-79022011-12-016420520910.1016/j.jds.2011.09.004Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinomaTzong-Ming Shieh0Shun-Yao Ko1Shu-Shin Chang2Kuo-Wei Chang3Yin-Hua Shih4Chung-Ji Liu5Department of Dental Hygiene, School of Health Care, China Medical University, Taichung, TaiwanGraduate Institute of Medical Science, Chang Jung Christian University, Tainan, TaiwanGraduate Institute of Medical Science, Chang Jung Christian University, Tainan, TaiwanInstitute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, TaiwanInstitute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, TaiwanInstitute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, TaiwanBackground/purpose: Oral squamous cell carcinoma (OSCC) is highly prevalent worldwide. Lysyl oxidase (LOX) is an important enzyme that modulates the extracellular matrix. The LOX superfamily contains LOX and LOX-like (LOXL) enzymes. The aim of the present study was to determine the expressions of LOXL genes in OSCC. Materials and methods: RT-PCR was performed to detect messenger (m)RNA expression of the LOXL genes, LOX-L1, -L3, and -L4, in paired OSCC and non-cancerous matched tissues (NCMTs). Results: Increased mRNA expressions of LOX-L1 and LOX-L3 in OSCC relative to NCMTs were identified in 41% and 65% of OSCC samples, respectively. The normalized mRNA expression of LOXL-3 was 1.11 ± 0.15 in OSCC, which was significantly higher than 0.68 ± 0.12 in NCMTs (P = 0.004). The increased expression of LOX-L3 was associated with worse survival of OSCC patients (P = 0.028). Conclusion: The results indicated the frequent increase in LOX-L3 mRNA expression in OSCC, and the value of LOX-L3 mRNA expression might have clinical uses in monitoring OSCC.http://www.sciencedirect.com/science/article/pii/S199179021100078Xlysyl oxidaselysyl oxidase-like protein 3oral squamous cell carcinomasurvival |
| spellingShingle | Tzong-Ming Shieh Shun-Yao Ko Shu-Shin Chang Kuo-Wei Chang Yin-Hua Shih Chung-Ji Liu Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma Journal of Dental Sciences lysyl oxidase lysyl oxidase-like protein 3 oral squamous cell carcinoma survival |
| title | Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma |
| title_full | Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma |
| title_fullStr | Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma |
| title_full_unstemmed | Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma |
| title_short | Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma |
| title_sort | lysyl oxidase like 3 mrna expression indicates poor survival from oral squamous cell carcinoma |
| topic | lysyl oxidase lysyl oxidase-like protein 3 oral squamous cell carcinoma survival |
| url | http://www.sciencedirect.com/science/article/pii/S199179021100078X |
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