Two old drugs, NVP-AEW541 and GSK-J4, repurposed against the Toxoplasma gondii RH strain

Two old drugs, NVP-AEW541 and GSK-J4, repurposed against the Toxoplasma gondii RH strain

Abstract Background Toxoplasma gondii is a zoonotic pathogen that causes toxoplasmosis and leads to serious public health problems in developing countries. However, current clinical therapeutic drugs have some disadvantages, such as serious side effects, a long course of treatment and the emergence...

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Bibliographic Details
Main Authors: Shuxian Liu, Mimi Wu, Qianqian Hua, Daiqiang Lu, Yuan Tian, Helin Yu, Linyan Cheng, Yinqi Chen, Jiaxin Cao, Xin Hu, Feng Tan
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Parasites & Vectors
Subjects:
NVP-AEW541
GSK-J4
Toxoplasma gondii
Invasion
Intracellular replication
In vivo
Online Access:http://link.springer.com/article/10.1186/s13071-020-04094-2

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