Tumour Stem Cells in Breast Cancer
Tumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in bre...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/9/5058 |
| _version_ | 1797504392796045312 |
|---|---|
| author | Marina Ibragimova Matvey Tsyganov Nikolai Litviakov |
| author_facet | Marina Ibragimova Matvey Tsyganov Nikolai Litviakov |
| author_sort | Marina Ibragimova |
| collection | DOAJ |
| description | Tumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in breast cancer (BC): CSC markers and signalling pathways, heterogeneity, plasticity, and ecological behaviour. The dynamic heterogeneity of CSCs and the dynamic transitions of CSC<sup>−</sup> non-CSCs and their significance for metastasis are considered. |
| first_indexed | 2024-03-10T04:03:58Z |
| format | Article |
| id | doaj.art-0f5369b243344904be732b23767dd6bb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:03:58Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0f5369b243344904be732b23767dd6bb2023-11-23T08:26:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239505810.3390/ijms23095058Tumour Stem Cells in Breast CancerMarina Ibragimova0Matvey Tsyganov1Nikolai Litviakov2Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5, Kooperativny Street, 634050 Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5, Kooperativny Street, 634050 Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5, Kooperativny Street, 634050 Tomsk, RussiaTumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in breast cancer (BC): CSC markers and signalling pathways, heterogeneity, plasticity, and ecological behaviour. The dynamic heterogeneity of CSCs and the dynamic transitions of CSC<sup>−</sup> non-CSCs and their significance for metastasis are considered.https://www.mdpi.com/1422-0067/23/9/5058cancer stem cellsbreast cancermetastasisplasticity |
| spellingShingle | Marina Ibragimova Matvey Tsyganov Nikolai Litviakov Tumour Stem Cells in Breast Cancer International Journal of Molecular Sciences cancer stem cells breast cancer metastasis plasticity |
| title | Tumour Stem Cells in Breast Cancer |
| title_full | Tumour Stem Cells in Breast Cancer |
| title_fullStr | Tumour Stem Cells in Breast Cancer |
| title_full_unstemmed | Tumour Stem Cells in Breast Cancer |
| title_short | Tumour Stem Cells in Breast Cancer |
| title_sort | tumour stem cells in breast cancer |
| topic | cancer stem cells breast cancer metastasis plasticity |
| url | https://www.mdpi.com/1422-0067/23/9/5058 |
| work_keys_str_mv | AT marinaibragimova tumourstemcellsinbreastcancer AT matveytsyganov tumourstemcellsinbreastcancer AT nikolailitviakov tumourstemcellsinbreastcancer |