Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux Nephropathy
Introduction: To evaluate the human leukocyte antigen (HLA) types of patients with vesicoureteral reflux (VUR) who underwent renal transplantation for end-stage renal disease (ESRD) to investigate for any significant association.Methods: This retrospective study comprised 26 patients (male, 15; fema...
| Váldodahkkit: | , , , , , , , , |
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| Materiálatiipa: | Artihkal |
| Giella: | English |
| Almmustuhtton: |
Galenos Yayinevi
2018-09-01
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| Ráidu: | İstanbul Medical Journal |
| Liŋkkat: |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/survey-of-hla-distribution-in-patients-with-end-st/20239
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| _version_ | 1828021229767884800 |
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| author | Rahşan Özcan Elif Altınay Kırlı Elif Kortan Salih Pekmezci Nurhan Seyahi Erkan Yılmaz Nur Canpolat Mehmet Rıza Altıparmak Mehmet Eliçevik |
| author_facet | Rahşan Özcan Elif Altınay Kırlı Elif Kortan Salih Pekmezci Nurhan Seyahi Erkan Yılmaz Nur Canpolat Mehmet Rıza Altıparmak Mehmet Eliçevik |
| author_sort | Rahşan Özcan |
| collection | DOAJ |
| description | Introduction: To evaluate the human leukocyte antigen (HLA) types of patients with vesicoureteral reflux (VUR) who underwent renal transplantation for end-stage renal disease (ESRD) to investigate for any significant association.Methods: This retrospective study comprised 26 patients (male, 15; female, 11) with ESRD secondary to VUR (ESRD/VUR group) who underwent renal transplantation, and 38 healthy donors (female, 24; male, 14) were randomized in the control group. The Single Specific Primer-Polymerase Chain Reaction (low resolution) method was performed for HLA typing. The statistical analyses included chi-square test and calculation of odds ratio (OR).Results: The median age was 25.2 years (R, 10-41) in the ESRD/VUR group and 43.9 (R, 20-76) in the control group. A statistically significant difference between HLA A and B types was not observed. The HLA DRB1*01 was significantly higher in the ESRD/VUR group than in the control group (p=0,024). The OR for the HLA DRB1*01 was 2.727. The risk of developing ESRD secondary to VUR was 2.727 times higher in the presence of the HLA DRB1*01.Conclusion: An association between HLA DRB1*01 and ESRD secondary to VUR was established. The HLA DRB1*01 antigen could be interpreted as a poor prognostic factor of reflux nephropathy. This finding should be supported by further studies. |
| first_indexed | 2024-04-10T11:49:01Z |
| format | Article |
| id | doaj.art-0f55269b66dc4763b391675a4ccbda9f |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T11:49:01Z |
| publishDate | 2018-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-0f55269b66dc4763b391675a4ccbda9f2023-02-15T16:17:11ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2018-09-0119325525710.5152/imj.2018.3274813049054Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux NephropathyRahşan Özcan0Elif Altınay Kırlı1Elif Kortan2Salih Pekmezci3Nurhan Seyahi4Erkan Yılmaz5Nur Canpolat6Mehmet Rıza Altıparmak7Mehmet Eliçevik8 Department of Pediatric Surgery, Division of Pediatric Urology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of Pediatric Surgery, Division of Pediatric Urology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of Pediatric Surgery, Division of Pediatric Urology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of General Surgery, İstanbul University- Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of Internal Medicine, Division of Nephrology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Blood Bank Tissue Typing Laboratory, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of Internal Medicine, Division of Pediatric Nephrology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of Internal Medicine, Division of Nephrology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of Pediatric Surgery, Division of Pediatric Urology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey Introduction: To evaluate the human leukocyte antigen (HLA) types of patients with vesicoureteral reflux (VUR) who underwent renal transplantation for end-stage renal disease (ESRD) to investigate for any significant association.Methods: This retrospective study comprised 26 patients (male, 15; female, 11) with ESRD secondary to VUR (ESRD/VUR group) who underwent renal transplantation, and 38 healthy donors (female, 24; male, 14) were randomized in the control group. The Single Specific Primer-Polymerase Chain Reaction (low resolution) method was performed for HLA typing. The statistical analyses included chi-square test and calculation of odds ratio (OR).Results: The median age was 25.2 years (R, 10-41) in the ESRD/VUR group and 43.9 (R, 20-76) in the control group. A statistically significant difference between HLA A and B types was not observed. The HLA DRB1*01 was significantly higher in the ESRD/VUR group than in the control group (p=0,024). The OR for the HLA DRB1*01 was 2.727. The risk of developing ESRD secondary to VUR was 2.727 times higher in the presence of the HLA DRB1*01.Conclusion: An association between HLA DRB1*01 and ESRD secondary to VUR was established. The HLA DRB1*01 antigen could be interpreted as a poor prognostic factor of reflux nephropathy. This finding should be supported by further studies. http://imj.galenos.com.tr/archives/archive-detail/article-preview/survey-of-hla-distribution-in-patients-with-end-st/20239 |
| spellingShingle | Rahşan Özcan Elif Altınay Kırlı Elif Kortan Salih Pekmezci Nurhan Seyahi Erkan Yılmaz Nur Canpolat Mehmet Rıza Altıparmak Mehmet Eliçevik Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux Nephropathy İstanbul Medical Journal |
| title | Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux Nephropathy |
| title_full | Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux Nephropathy |
| title_fullStr | Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux Nephropathy |
| title_full_unstemmed | Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux Nephropathy |
| title_short | Survey of HLA Distribution in Patients with End Stage Renal Disease Secondary to Reflux Nephropathy |
| title_sort | survey of hla distribution in patients with end stage renal disease secondary to reflux nephropathy |
| url |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/survey-of-hla-distribution-in-patients-with-end-st/20239
|
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