Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection.

Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection.

Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine gradients that direct local leukocyte chemotaxis into damaged or transplanted tissues. While chemokine-receptor binding has been extensively studied dur...

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Bibliographic Details
Main Authors: Erbin Dai, Li-Ying Liu, Hao Wang, Dana McIvor, Yun Ming Sun, Colin Macaulay, Elaine King, Ganesh Munuswamy-Ramanujam, Mee Yong Bartee, Jennifer Williams, Jennifer Davids, Israel Charo, Grant McFadden, Jeffrey D Esko, Alexandra R Lucas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2865544?pdf=render

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