Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitus
Objective: To analyze the characteristics of pregnant women with pre-gestational diabetes mellitus (PGDM) who had missed diagnosis prior to pregnancy, and to evaluate the effects of diagnosis time on pregnancy outcomes in pregnant women with PGDM. Materials and Methods: A total of 822 pregnant women...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.4998 |
| _version_ | 1828224438714236928 |
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| author | Hongying Zhang Qingling Wei Jinlan Wei Haiyang Pang Wenxuan Wei Yu Sun Mengya He Yanling Sun |
| author_facet | Hongying Zhang Qingling Wei Jinlan Wei Haiyang Pang Wenxuan Wei Yu Sun Mengya He Yanling Sun |
| author_sort | Hongying Zhang |
| collection | DOAJ |
| description | Objective: To analyze the characteristics of pregnant women with pre-gestational diabetes mellitus (PGDM) who had missed diagnosis prior to pregnancy, and to evaluate the effects of diagnosis time on pregnancy outcomes in pregnant women with PGDM. Materials and Methods: A total of 822 pregnant women who were diagnosed with PGDM were conducted in this study. They were divided into two groups, including pre-pregnancy diagnosis group and pregnancy diagnosis group based on the initial diagnosis time. Then in the pregnancy diagnosis group, the cases diagnosed before 24 gestational weeks were defined as group A, and those diagnosed at or after 24 gestational weeks were defined as Group B. Maternal and pregnancy variables, as well as pregnancy outcomes, including delivery age of pregnant women, the rate of pregnancy loss, delivery gestational weeks, neonatal birth weight, the proportion of insulin treatment, the rate of pre-term, macrosomia, newborns transferred to pediatrics, the average of HbA1c level, and preeclampsia, were analyzed among groups by paired Student’s t-test. Results: The rate of missed diagnosis before pregnancy was 68.1%. The proportion of insulin treatment and the rate of the cesarean section had a significant difference between pre-pregnancy diagnosis group and pregnancy diagnosis group. The characteristics and pregnancy outcomes in pregnancy diagnosis group A were not significantly different from those in the pre-pregnancy diagnosis group. However, in the pregnancy diagnosis group B, the proportion of pregnant women using insulin treatment and the average HbA1c level had a statistically significant difference, compared to pregnancy diagnosis group A, as well as the pre-pregnancy group. Conclusions: The rate of undiagnosed PGDM was high, and PGDM was significantly associated with multiple adverse pregnancy outcomes. Fasting plasma glucose should be used as a screening test to identify PGDM at pre-pregnancy or first antenatal care. |
| first_indexed | 2024-04-12T17:19:26Z |
| format | Article |
| id | doaj.art-0f593342bd6942c395644e10b0b11534 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-12T17:19:26Z |
| publishDate | 2020-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-0f593342bd6942c395644e10b0b115342022-12-22T03:23:31ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-02-01471576110.31083/j.ceog.2020.01.4998S0390-6663(20)00204-3Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitusHongying Zhang0Qingling Wei1Jinlan Wei2Haiyang Pang3Wenxuan Wei4Yu Sun5Mengya He6Yanling Sun7Department of Obstetrics, Yidu Central Hospital of Weifang, Shandong, ChinaDepartment of Public Health, Yidu Central Hospital of Weifang, Shandong, ChinaDepartment of Public Health, Yidu Central Hospital of Weifang, Shandong, ChinaDepartment of Rehabilitation Medicine, Pingdu Peoples's Hospital, Shandong, ChinaDepartment of Obstetrics, Yidu Central Hospital of Weifang, Shandong, ChinaDepartment of Obstetrics, Yidu Central Hospital of Weifang, Shandong, ChinaDepartment of Obstetrics, Yidu Central Hospital of Weifang, Shandong, ChinaDepartment of Obstetrics, Yidu Central Hospital of Weifang, Shandong, ChinaObjective: To analyze the characteristics of pregnant women with pre-gestational diabetes mellitus (PGDM) who had missed diagnosis prior to pregnancy, and to evaluate the effects of diagnosis time on pregnancy outcomes in pregnant women with PGDM. Materials and Methods: A total of 822 pregnant women who were diagnosed with PGDM were conducted in this study. They were divided into two groups, including pre-pregnancy diagnosis group and pregnancy diagnosis group based on the initial diagnosis time. Then in the pregnancy diagnosis group, the cases diagnosed before 24 gestational weeks were defined as group A, and those diagnosed at or after 24 gestational weeks were defined as Group B. Maternal and pregnancy variables, as well as pregnancy outcomes, including delivery age of pregnant women, the rate of pregnancy loss, delivery gestational weeks, neonatal birth weight, the proportion of insulin treatment, the rate of pre-term, macrosomia, newborns transferred to pediatrics, the average of HbA1c level, and preeclampsia, were analyzed among groups by paired Student’s t-test. Results: The rate of missed diagnosis before pregnancy was 68.1%. The proportion of insulin treatment and the rate of the cesarean section had a significant difference between pre-pregnancy diagnosis group and pregnancy diagnosis group. The characteristics and pregnancy outcomes in pregnancy diagnosis group A were not significantly different from those in the pre-pregnancy diagnosis group. However, in the pregnancy diagnosis group B, the proportion of pregnant women using insulin treatment and the average HbA1c level had a statistically significant difference, compared to pregnancy diagnosis group A, as well as the pre-pregnancy group. Conclusions: The rate of undiagnosed PGDM was high, and PGDM was significantly associated with multiple adverse pregnancy outcomes. Fasting plasma glucose should be used as a screening test to identify PGDM at pre-pregnancy or first antenatal care.https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.4998pre-gestational diabetes mellituspregnancy outcomediagnosis time |
| spellingShingle | Hongying Zhang Qingling Wei Jinlan Wei Haiyang Pang Wenxuan Wei Yu Sun Mengya He Yanling Sun Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitus Clinical and Experimental Obstetrics & Gynecology pre-gestational diabetes mellitus pregnancy outcome diagnosis time |
| title | Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitus |
| title_full | Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitus |
| title_fullStr | Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitus |
| title_full_unstemmed | Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitus |
| title_short | Importance of diagnosis time on pregnancy outcomes in pregnant women with pre-gestational diabetes mellitus |
| title_sort | importance of diagnosis time on pregnancy outcomes in pregnant women with pre gestational diabetes mellitus |
| topic | pre-gestational diabetes mellitus pregnancy outcome diagnosis time |
| url | https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.4998 |
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