The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition
A crucial etiological component in fetal programming is early nutrition. Indeed, early undernutrition may cause a chronic increase in blood pressure and cardiovascular diseases, including stroke and heart failure. In this regard, current evidence has sustained several pathological mechanisms involvi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11965 |
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| author | Bernardita Cayupe Blanca Troncoso Carlos Morgan Patricio Sáez-Briones Ramón Sotomayor-Zárate Luis Constandil Alejandro Hernández Eugenia Morselli Rafael Barra |
| author_facet | Bernardita Cayupe Blanca Troncoso Carlos Morgan Patricio Sáez-Briones Ramón Sotomayor-Zárate Luis Constandil Alejandro Hernández Eugenia Morselli Rafael Barra |
| author_sort | Bernardita Cayupe |
| collection | DOAJ |
| description | A crucial etiological component in fetal programming is early nutrition. Indeed, early undernutrition may cause a chronic increase in blood pressure and cardiovascular diseases, including stroke and heart failure. In this regard, current evidence has sustained several pathological mechanisms involving changes in central and peripheral targets. In the present review, we summarize the neuroendocrine and neuroplastic modifications that underlie maladaptive mechanisms related to chronic hypertension programming after early undernutrition. First, we analyzed the role of glucocorticoids on the mechanism of long-term programming of hypertension. Secondly, we discussed the pathological plastic changes at the paraventricular nucleus of the hypothalamus that contribute to the development of chronic hypertension in animal models of prenatal undernutrition, dissecting the neural network that reciprocally communicates this nucleus with the locus coeruleus. Finally, we propose an integrated and updated view of the main neuroendocrine and central circuital alterations that support the occurrence of chronic increases of blood pressure in prenatally undernourished animals. |
| first_indexed | 2024-03-09T21:35:57Z |
| format | Article |
| id | doaj.art-0f596bca39fe499490dba79f532c6e1f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:35:57Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0f596bca39fe499490dba79f532c6e1f2023-11-23T20:42:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191196510.3390/ijms231911965The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal UndernutritionBernardita Cayupe0Blanca Troncoso1Carlos Morgan2Patricio Sáez-Briones3Ramón Sotomayor-Zárate4Luis Constandil5Alejandro Hernández6Eugenia Morselli7Rafael Barra8Centro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile (USACH), Santiago 9170020, ChileEscuela de Enfermería, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170020, ChileLaboratorio de Neurofarmacología y Comportamiento, Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170020, ChileLaboratorio de Neurofarmacología y Comportamiento, Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170020, ChileLaboratorio de Neuroquímica y Neurofarmacología, Centro de Neurobiología y Fisiopatología Integrativa, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, ChileLaboratorio de Neurobiología, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170020, ChileLaboratorio de Neurobiología, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170020, ChileDepartment of Basic Sciences, Faculty of Medicine and Sciences, Universidad San Sebastián, Santiago 7510157, ChileCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile (USACH), Santiago 9170020, ChileA crucial etiological component in fetal programming is early nutrition. Indeed, early undernutrition may cause a chronic increase in blood pressure and cardiovascular diseases, including stroke and heart failure. In this regard, current evidence has sustained several pathological mechanisms involving changes in central and peripheral targets. In the present review, we summarize the neuroendocrine and neuroplastic modifications that underlie maladaptive mechanisms related to chronic hypertension programming after early undernutrition. First, we analyzed the role of glucocorticoids on the mechanism of long-term programming of hypertension. Secondly, we discussed the pathological plastic changes at the paraventricular nucleus of the hypothalamus that contribute to the development of chronic hypertension in animal models of prenatal undernutrition, dissecting the neural network that reciprocally communicates this nucleus with the locus coeruleus. Finally, we propose an integrated and updated view of the main neuroendocrine and central circuital alterations that support the occurrence of chronic increases of blood pressure in prenatally undernourished animals.https://www.mdpi.com/1422-0067/23/19/11965prenatal undernutritionhypertensionparaventicular nucleuslocus coeruleusneural network |
| spellingShingle | Bernardita Cayupe Blanca Troncoso Carlos Morgan Patricio Sáez-Briones Ramón Sotomayor-Zárate Luis Constandil Alejandro Hernández Eugenia Morselli Rafael Barra The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition International Journal of Molecular Sciences prenatal undernutrition hypertension paraventicular nucleus locus coeruleus neural network |
| title | The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition |
| title_full | The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition |
| title_fullStr | The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition |
| title_full_unstemmed | The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition |
| title_short | The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition |
| title_sort | role of the paraventricular coerulear network on the programming of hypertension by prenatal undernutrition |
| topic | prenatal undernutrition hypertension paraventicular nucleus locus coeruleus neural network |
| url | https://www.mdpi.com/1422-0067/23/19/11965 |
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