The Effect of Flutamide on Ovulation Induction in PCOS Patients
Background Polycystic ovary syndrome (PCOS) is a disorder that affects various body organs and requires comprehensive long term evaluation and management. The aim of this study was to evaluate effect of Flutamide on ovulation induction in PCOS patients. Materials and Methods This prospective...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2012-04-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | http://www.ijfs.ir/article_45125_21d99ec1f96006e24993a1c9fd0382e1.pdf |
| _version_ | 1818347890547884032 |
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| author | Tahereh Madani Shohreh Irani Mahnaz Ashrafi Maryam Alsadat Nabavi |
| author_facet | Tahereh Madani Shohreh Irani Mahnaz Ashrafi Maryam Alsadat Nabavi |
| author_sort | Tahereh Madani |
| collection | DOAJ |
| description | Background Polycystic ovary syndrome (PCOS) is a disorder that affects various body organs and requires comprehensive long term evaluation and management. The aim of this study was to evaluate effect of Flutamide on ovulation induction in PCOS patients. Materials and Methods This prospective study applied triple blind method, a simple convenience sampling method, to induce ovulations of the ninety six PCOS patients. Patients were divided into two groups; group A included 53 subjects (received Flutamide + Clomiphene Citrate) and group B included 43 subjects (received placebo + Clomiphene Citrate). Ultrasound was carried to determine the size of follicles and growth rate of them during follicular phase of the menstrual cycle. Also, progesterone levels were measured on days 19 and 21 of the menstrual cycle. Results In this study, ninety six PCOS patients, in two treatment and control groups, were evaluated regarding to body mass index (BMI), cycle irregularity, age and number of dominant follicles, duration of stimulation, endocrine profile and score of hirsutism. The obtained results revealed no significant differences between two groups. Conclusion Flutamide does not affect ovulation improvement in PCOS patients undergoing induction (Registration Number: IRCT 201105081141N10). |
| first_indexed | 2024-12-13T17:41:21Z |
| format | Article |
| id | doaj.art-0f5a9153794140688833e93382c1b9a9 |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-13T17:41:21Z |
| publishDate | 2012-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-0f5a9153794140688833e93382c1b9a92022-12-21T23:36:44ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782012-04-0161656945125The Effect of Flutamide on Ovulation Induction in PCOS PatientsTahereh Madani0Shohreh Irani1Mahnaz Ashrafi2Maryam Alsadat Nabavi3Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranEpidemiology and Reproductive Health Department, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranBackground Polycystic ovary syndrome (PCOS) is a disorder that affects various body organs and requires comprehensive long term evaluation and management. The aim of this study was to evaluate effect of Flutamide on ovulation induction in PCOS patients. Materials and Methods This prospective study applied triple blind method, a simple convenience sampling method, to induce ovulations of the ninety six PCOS patients. Patients were divided into two groups; group A included 53 subjects (received Flutamide + Clomiphene Citrate) and group B included 43 subjects (received placebo + Clomiphene Citrate). Ultrasound was carried to determine the size of follicles and growth rate of them during follicular phase of the menstrual cycle. Also, progesterone levels were measured on days 19 and 21 of the menstrual cycle. Results In this study, ninety six PCOS patients, in two treatment and control groups, were evaluated regarding to body mass index (BMI), cycle irregularity, age and number of dominant follicles, duration of stimulation, endocrine profile and score of hirsutism. The obtained results revealed no significant differences between two groups. Conclusion Flutamide does not affect ovulation improvement in PCOS patients undergoing induction (Registration Number: IRCT 201105081141N10).http://www.ijfs.ir/article_45125_21d99ec1f96006e24993a1c9fd0382e1.pdfpolycystic ovary syndromeflutamideovulation induction |
| spellingShingle | Tahereh Madani Shohreh Irani Mahnaz Ashrafi Maryam Alsadat Nabavi The Effect of Flutamide on Ovulation Induction in PCOS Patients International Journal of Fertility and Sterility polycystic ovary syndrome flutamide ovulation induction |
| title | The Effect of Flutamide on Ovulation Induction in PCOS Patients |
| title_full | The Effect of Flutamide on Ovulation Induction in PCOS Patients |
| title_fullStr | The Effect of Flutamide on Ovulation Induction in PCOS Patients |
| title_full_unstemmed | The Effect of Flutamide on Ovulation Induction in PCOS Patients |
| title_short | The Effect of Flutamide on Ovulation Induction in PCOS Patients |
| title_sort | effect of flutamide on ovulation induction in pcos patients |
| topic | polycystic ovary syndrome flutamide ovulation induction |
| url | http://www.ijfs.ir/article_45125_21d99ec1f96006e24993a1c9fd0382e1.pdf |
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