Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study
BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).MethodsWe conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.858851/full |
| _version_ | 1811325697197604864 |
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| author | Lin Wang Lin Wang Chao Zhang Chao Zhang Hao Liang Hao Liang Nian Zhou Nian Zhou Tianji Huang Tianji Huang Zenghui Zhao Zenghui Zhao Xiaoji Luo Xiaoji Luo |
| author_facet | Lin Wang Lin Wang Chao Zhang Chao Zhang Hao Liang Hao Liang Nian Zhou Nian Zhou Tianji Huang Tianji Huang Zenghui Zhao Zenghui Zhao Xiaoji Luo Xiaoji Luo |
| author_sort | Lin Wang |
| collection | DOAJ |
| description | BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).MethodsWe conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.ResultsOur findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: −0.0515; 95% confidence interval [CI]: −0.0911 to −0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: −0.0699; 95% CI: −0.1304 to −0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.ConclusionThis two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism. |
| first_indexed | 2024-04-13T14:37:33Z |
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| language | English |
| last_indexed | 2024-04-13T14:37:33Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-0f5ac3921ada4908b1948e1bcae5b9612022-12-22T02:42:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.858851858851Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization StudyLin Wang0Lin Wang1Chao Zhang2Chao Zhang3Hao Liang4Hao Liang5Nian Zhou6Nian Zhou7Tianji Huang8Tianji Huang9Zenghui Zhao10Zenghui Zhao11Xiaoji Luo12Xiaoji Luo13Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOrthopedic Laboratory of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOrthopedic Laboratory of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOrthopedic Laboratory of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOrthopedic Laboratory of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOrthopedic Laboratory of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOrthopedic Laboratory of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaOrthopedic Laboratory of Chongqing Medical University, Chongqing, ChinaBackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).MethodsWe conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.ResultsOur findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: −0.0515; 95% confidence interval [CI]: −0.0911 to −0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: −0.0699; 95% CI: −0.1304 to −0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.ConclusionThis two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism.https://www.frontiersin.org/articles/10.3389/fendo.2022.858851/fullpolyunsaturated fatty acids - PUFAbone mineral density—BMDmendelian randomizationosteoporosisomega - 3 fatty acids |
| spellingShingle | Lin Wang Lin Wang Chao Zhang Chao Zhang Hao Liang Hao Liang Nian Zhou Nian Zhou Tianji Huang Tianji Huang Zenghui Zhao Zenghui Zhao Xiaoji Luo Xiaoji Luo Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study Frontiers in Endocrinology polyunsaturated fatty acids - PUFA bone mineral density—BMD mendelian randomization osteoporosis omega - 3 fatty acids |
| title | Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study |
| title_full | Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study |
| title_fullStr | Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study |
| title_full_unstemmed | Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study |
| title_short | Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study |
| title_sort | polyunsaturated fatty acids level and bone mineral density a two sample mendelian randomization study |
| topic | polyunsaturated fatty acids - PUFA bone mineral density—BMD mendelian randomization osteoporosis omega - 3 fatty acids |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.858851/full |
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