Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms
<i>Background and Objectives:</i> Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4−9%. Linking certain factors to cerebral aneurysm rupture c...
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| Format: | Article |
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MDPI AG
2019-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/7/338 |
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| author | Nebojša N. Stojanović Aleksandar Kostić Radisav Mitić Luka Berilažić Miša Radisavljević |
| author_facet | Nebojša N. Stojanović Aleksandar Kostić Radisav Mitić Luka Berilažić Miša Radisavljević |
| author_sort | Nebojša N. Stojanović |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4−9%. Linking certain factors to cerebral aneurysm rupture could help in explaining the significantly lower incidence of their rupture compared to their presence. The aim of this study is to determine the association between the corresponding circle of Willis configurations and rupture of cerebral aneurysms. <i>Materials and Methods:</i> A group of 114 patients treated operatively for aruptured cerebral aneurysm and a group of 56 autopsied subjects were involved in the study. Four basic types of the circle of Willis configurations were formed—two symmetric types A and C, and two asymmetric types B and D. <i>Results:</i> A statistically significantly higher presence of asymmetry of the circle of Willis was determined in the group of surgically-treated subjects (<i>p</i> = 0.001),witha significant presence of asymmetric Type B in this group (<i>p</i> < 0.001). The changeson the A1 segment in the group of surgically-treated subjects showed a statistically significant presence compared to the group of autopsied subjects (<i>p</i> = 0.001). Analyzing the presence of symmetry of the circle of Willis between the two groups, that is, the total presence of symmetric types A and C, indicated their statistically significant presence in the group of autopsied patients (<i>p</i> < 0.001)<i>. Conclusions:</i> Changes such as hypoplasia or aplasia of A1 and the resulting asymmetry of the circle of Willis directly affect the possibility of the rupture of cerebral aneurysms. Detection of the corresponding types of the circle of Willis after diagnostic examination can be the basis for the development of a protocol for monitoring such patients. |
| first_indexed | 2024-03-12T09:30:51Z |
| format | Article |
| id | doaj.art-0f5f1324acab48b19f3796c64481ec82 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:30:51Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-0f5f1324acab48b19f3796c64481ec822023-09-02T13:54:08ZengMDPI AGMedicina1010-660X2019-07-0155733810.3390/medicina55070338medicina55070338Association between Circle of Willis Configuration and Rupture of Cerebral AneurysmsNebojša N. Stojanović0Aleksandar Kostić1Radisav Mitić2Luka Berilažić3Miša Radisavljević4Clinic of Neurosurgery, Clinical Center Niš, Zorana Đinđića 48, 18000 Niš, SerbiaClinic of Neurosurgery, Clinical Center Niš, Zorana Đinđića 48, 18000 Niš, SerbiaClinic of Neurosurgery, Clinical Center Niš, Zorana Đinđića 48, 18000 Niš, SerbiaClinic of Neurosurgery, Clinical Center Niš, Zorana Đinđića 48, 18000 Niš, SerbiaClinic of Neurosurgery, Clinical Center Niš, Zorana Đinđića 48, 18000 Niš, Serbia<i>Background and Objectives:</i> Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4−9%. Linking certain factors to cerebral aneurysm rupture could help in explaining the significantly lower incidence of their rupture compared to their presence. The aim of this study is to determine the association between the corresponding circle of Willis configurations and rupture of cerebral aneurysms. <i>Materials and Methods:</i> A group of 114 patients treated operatively for aruptured cerebral aneurysm and a group of 56 autopsied subjects were involved in the study. Four basic types of the circle of Willis configurations were formed—two symmetric types A and C, and two asymmetric types B and D. <i>Results:</i> A statistically significantly higher presence of asymmetry of the circle of Willis was determined in the group of surgically-treated subjects (<i>p</i> = 0.001),witha significant presence of asymmetric Type B in this group (<i>p</i> < 0.001). The changeson the A1 segment in the group of surgically-treated subjects showed a statistically significant presence compared to the group of autopsied subjects (<i>p</i> = 0.001). Analyzing the presence of symmetry of the circle of Willis between the two groups, that is, the total presence of symmetric types A and C, indicated their statistically significant presence in the group of autopsied patients (<i>p</i> < 0.001)<i>. Conclusions:</i> Changes such as hypoplasia or aplasia of A1 and the resulting asymmetry of the circle of Willis directly affect the possibility of the rupture of cerebral aneurysms. Detection of the corresponding types of the circle of Willis after diagnostic examination can be the basis for the development of a protocol for monitoring such patients.https://www.mdpi.com/1010-660X/55/7/338cerebral aneurysmscircle of Willis |
| spellingShingle | Nebojša N. Stojanović Aleksandar Kostić Radisav Mitić Luka Berilažić Miša Radisavljević Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms Medicina cerebral aneurysms circle of Willis |
| title | Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms |
| title_full | Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms |
| title_fullStr | Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms |
| title_full_unstemmed | Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms |
| title_short | Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms |
| title_sort | association between circle of willis configuration and rupture of cerebral aneurysms |
| topic | cerebral aneurysms circle of Willis |
| url | https://www.mdpi.com/1010-660X/55/7/338 |
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