Hypertension and obstructive sleep apnea
Craig L Phillips,1–3 Denise M O'Driscoll4,51Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia; 2National Health and Medical Research Council Center for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-05-01
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| Series: | Nature and Science of Sleep |
| Online Access: | http://www.dovepress.com/hypertension-and-obstructive-sleep-apnea-a13018 |
| _version_ | 1818400966999801856 |
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| author | Phillips CL O'Driscoll DM |
| author_facet | Phillips CL O'Driscoll DM |
| author_sort | Phillips CL |
| collection | DOAJ |
| description | Craig L Phillips,1–3 Denise M O'Driscoll4,51Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia; 2National Health and Medical Research Council Center for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia; 3Discipline of Sleep Medicine, Sydney Medical School, University of Sydney, Sydney, Australia; 4Monash Lung and Sleep, Monash Medical Centre, Monash University, Melbourne, Australia; 5Department of Medicine, Southern Clinical School, Monash University, Melbourne, AustraliaAbstract: Obstructive sleep apnea (OSA) is increasingly being recognized as a major health burden with strong focus on the associated cardiovascular risk. Studies from the last two decades have provided strong evidence for a causal role of OSA in the development of systemic hypertension. The acute physiological changes that occur during apnea promote nocturnal hypertension and may lead to the development of sustained daytime hypertension via the pathways of sympathetic activation, inflammation, oxidative stress, and endothelial dysfunction. This review will focus on the acute hemodynamic disturbances and associated intermittent hypoxia that characterize OSA and the potential pathophysiological mechanisms responsible for the development of hypertension in OSA. In addition the epidemiology of OSA and hypertension, as well as the role of treatment of OSA, in improving blood pressure control will be examined.Keywords: obstructive sleep apnea, hypertension, intermittent hypoxia, ambulatory blood pressure, sympathetic activation |
| first_indexed | 2024-12-14T07:44:59Z |
| format | Article |
| id | doaj.art-0f6126c2412d4373856c20559eafd830 |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-12-14T07:44:59Z |
| publishDate | 2013-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-0f6126c2412d4373856c20559eafd8302022-12-21T23:10:55ZengDove Medical PressNature and Science of Sleep1179-16082013-05-012013default4352Hypertension and obstructive sleep apneaPhillips CLO'Driscoll DMCraig L Phillips,1–3 Denise M O'Driscoll4,51Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia; 2National Health and Medical Research Council Center for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia; 3Discipline of Sleep Medicine, Sydney Medical School, University of Sydney, Sydney, Australia; 4Monash Lung and Sleep, Monash Medical Centre, Monash University, Melbourne, Australia; 5Department of Medicine, Southern Clinical School, Monash University, Melbourne, AustraliaAbstract: Obstructive sleep apnea (OSA) is increasingly being recognized as a major health burden with strong focus on the associated cardiovascular risk. Studies from the last two decades have provided strong evidence for a causal role of OSA in the development of systemic hypertension. The acute physiological changes that occur during apnea promote nocturnal hypertension and may lead to the development of sustained daytime hypertension via the pathways of sympathetic activation, inflammation, oxidative stress, and endothelial dysfunction. This review will focus on the acute hemodynamic disturbances and associated intermittent hypoxia that characterize OSA and the potential pathophysiological mechanisms responsible for the development of hypertension in OSA. In addition the epidemiology of OSA and hypertension, as well as the role of treatment of OSA, in improving blood pressure control will be examined.Keywords: obstructive sleep apnea, hypertension, intermittent hypoxia, ambulatory blood pressure, sympathetic activationhttp://www.dovepress.com/hypertension-and-obstructive-sleep-apnea-a13018 |
| spellingShingle | Phillips CL O'Driscoll DM Hypertension and obstructive sleep apnea Nature and Science of Sleep |
| title | Hypertension and obstructive sleep apnea |
| title_full | Hypertension and obstructive sleep apnea |
| title_fullStr | Hypertension and obstructive sleep apnea |
| title_full_unstemmed | Hypertension and obstructive sleep apnea |
| title_short | Hypertension and obstructive sleep apnea |
| title_sort | hypertension and obstructive sleep apnea |
| url | http://www.dovepress.com/hypertension-and-obstructive-sleep-apnea-a13018 |
| work_keys_str_mv | AT phillipscl hypertensionandobstructivesleepapnea AT oamp39driscolldm hypertensionandobstructivesleepapnea |